p38MAPK pathways are central to inflammatory processes. The p38MAPK group has four members encoded by different genes, p38a, p38b, p38g and p38d. While the roles of the p38a isoform have been widely studied in the context of inflammation and tumour development, the knowledge of the in vivo role of p38g and p38d in these processes is still very limited. Our laboratory is studying essential functions of these two less studied alternative p38MAPKs, in vivo and in cultured cells. This strategy has lead to the discovery of unexpected cross talk between p38g/p38d and ERK1/2 pathway controlling cytokine production in cells during inflammation. The regulation of inflammatory processes by p38g/p38d has an impact in the development of different diseases such as colon and skin inflammation, arthritis, or colon cancer associated to colitis. We will discuss how, in specific settings, the p38MAPK components, p38γ and p38δ, operate in inflammatory processes, and the mechanisms underlying these unexpected functions.