Dr. Whiteley received her PhD in 2013 from UCSF where the focus of her thesis was on the regulation and function of FceR1 on human dendritic cells. She then spent two years as a postdoc at Genentech, and since 2016 she has been a postdoc at Harvard medical school.
Alex’s recent work has focused on Ubiquilins (Ubqlns), a family of proteasome receptors that facilitate the degradation of some ubiquitinated proteins by bringing them to the proteasome. By focusing on the physiological consequences of Ubqln perturbation, her research aims to get a clearer understanding of how proteome dysregulation influences disease - from immunity to neurodegeneration. Her work explores the roles of Ubqln 1 in regulating degradation of mislocalized mitochondrial proteins and how this influences B cell proliferation upon activation. She will also discuss her very recent work on how Ubqln 2 regulates protein degradation, and how this influences neurodegenerative disease.