In recent years the pervasive action of type I IFN (IFNs-a/b) in human physiology and in several pathological conditions has become evident. Actors of the immediate defence against viruses, these cytokines contribute to innate and adaptive immune cell functions and beyond. Perturbations of the IFN system can lead to altered immune responses, chronic inflammation and tissue damage as in the rare mendelian interferonopathies, in auto-immune diseases and some chronic viral infections.
My laboratory is interested in dissecting molecular mechanisms that mediate the pleiotropy and plasticity of type I IFN. I will present our studies on JAK/STAT effectors, regulatory loops and cross-talks of the type I IFN signaling pathway. This work may help to understand progression from beneficial to pathogenic IFN.