University of Dundee

‘Interleukin-27 as a novel therapy for inflammatory bowel disease’

Event Date: 
Wednesday, November 21, 2018 - 12:00
Event Location: 
CTIR Sir Kenneth and Lady Noreen Murray Seminar Room
Host: 
Professor Paul Crocker FRSE
Event Speaker: 
Dr Mairi McLean
Institution: 
School of Medicine, Medical Sciences & Nutrition University of Aberdeen
Event Type: 
Dundee Cell Signalling Lecture
Share
 
Tayside Immunology Group and the Division of Cell Signalling and Immunology
 

All Welcome

 

 

 

 

Abstract: 

 

Dr McLean’s research program focuses on cytokine immunology and epithelial barrier dysfunction in gastrointestinal pathology, including inflammatory bowel disease (IBD) and GI malignancy. IBD is a disabling lifelong condition and is increasing in incidence. Not all patients respond to, or are able to tolerate, currently available treatments. Therefore there is an unmet clinical need for new, safer treatments for IBD. Dr McLean has demonstrated that oral delivery of the immunoregulatory cytokine interleukin-27 (IL-27) is effective as a new therapy for IBD in pre-clinical mouse models of disease, through inhibition of multiple aspects of the innate and adaptive colonic immune responses. The lab is now translating this pre-clinical data to human tissue, characterising the impact of IL-27 on epithelial barrier healing using a human gastrointestinal tissue derived epithelial organoid model and defining the immunoregulatory capacity of IL-27 on human colon derived immune cell responses.