University of Dundee

" Functional characterization of the conserved kinase/ATPase Rio1 in yeast: from kinetochores to its global network and back..."

Event Date: 
Tuesday, November 27, 2018 - 12:00 to 13:00
Event Location: 
CTIR Sir Kenneth and Lady Noreen Murray Seminar Room
Host: 
Professor Tomo Tanaka FRSE
Event Speaker: 
Prof Peter de Wulf
Institution: 
University Trento, Italy
Event Type: 
Seminar
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Abstract
The dual-specificity kinase/ATPase Rio1, which is conserved from archaea to humans, is best known for contributing to pre-rRNA processing and the maturation of the small ribosomal subunit. However, in S. cerevisiae we identified Rio1 at kinetochores/centromeres and at the rDNA (nucleolus). I will discuss its roles at both sites and will place these activities within a conserved, global framework that Rio1 manages at the protein, gene, and RNA levels, allowing cells to grow, divide and faithfully transmit its genome in response to stress and nutritional conditions encountered.