University of Dundee

“From Penicillins to Epigenetics – Adventures at the Interface of Chemistry and Biology”

Event Date: 
Wednesday, November 14, 2018 - 14:30 to 15:30
Event Location: 
CTIR Sir Kenneth and Lady Noreen Murray Seminar Room
Host: 
Professor Alessio Ciulli FRSC
Professor Tom Owen-Hughes FRSE
Dr Sarah Coulthurst
Event Speaker: 
Professor Chris Schofield
Institution: 
University of Oxford
Event Type: 
Seminar
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Joint BCDD / MMB / GRE External Seminar

 

 

Abstract

Metallo enzymes play roles in the biosynthesis (FeII-oxygenases) of beta-lactam antibiotics, such as the penicillins, and in resistance mechanisms to them (ZnII-beta-lactamases). Human homologues of these bacterial enzymes have roles including in the regulation of protein biosynthesis, the hypoxic response and in nucleic acid damage repair. The lecture will describe work on the structures, mechanisms and biological roles of these two families of metallo-enzymes. It will then describe how their inhibition is being exploited in the development of new therapies for the treatment of diseases including anaemia and methods for combating antibacterial resistance.

 

 

Brief Biography 

Chris Schofield studied for a degree in chemistry at the University of Manchester (1979-1982). In 1982 he moved to Oxford for DPhil studies with Jack Baldwin on the synthesis and biosynthesis of antibiotics. In 1985 he became a Departmental Demonstrator in the Dyson Perrins Laboratory, and in 1990 Lecturer in Chemistry and Fellow of Hertford College. In 1998 he became Professor of Chemistry, and in 2011 was appointed Head of Organic Chemistry. He is a Fellow of the Royal Society.

 

Chris is one of the UKs leading organic chemist and chemical biologist

His research group works at the interface of chemistry, biology and medicine. His work has opened up new fields in antibiotic research, oxygen sensing and gene regulation in organisms ranging from bacteria to plants and animals, and has identified new opportunities for medicinal intervention that are being pursued by numerous academic and commercial laboratories.