University of Dundee

‘Poly(ADP-ribosylation) regulates key features of motor neuron disease’

Event Date: 
Friday, November 30, 2018 - 13:00 to 14:00
Event Location: 
MSI Small Lecture Theatre
Host: 
Professor Tom Owen-Hughes FRSE
Professor Kate Storey FRSE FMedSci FRSB
Event Speaker: 
Leeanne McGurk
Institution: 
University of Pennsylvania
Event Type: 
Seminar
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Joint GRE/CDB Seminar 

Abstract

In >95% of motor neuron disease (MND) the normally nuclear protein TDP-43 exits the nucleus and accumulates as hyperphosphorylated cytoplasmic aggregates in affected neurons and glia. Insight into the cellular mechanisms that trigger the nuclear clearance and subsequent phosphorylation of TDP-43 may provide a platform for the development of novel therapeutic strategies. Today I will demonstrate that poly(ADP-ribosylation), a reversible protein modification, regulates disease-associated toxicity, subcellular localization and hyperphosphorylation of TDP-43. These findings implicate poly(ADP-ribosylation) activity as a potential therapeutic target in MND and pave the way for future studies into the broader role of poly(ADP-ribosylation) in the nervous system.