Tuesday, December 4, 2018 - 12:00 to 13:00
WTB Seminar Rooms
Professor Paul Crocker FRSE
Dr Aaron Thomas Whiteley
Harvard Medical School
Dundee Cell Signalling Lecture
Tayside Immunology Group and the Division of Cell Signalling and Immunology
Cyclic dinucleotides (CDNs) play central roles in bacterial homeostasis and virulence as nucleotide second messengers. Bacterial CDNs also elicit immune responses during infection when they are detected by pattern recognition receptors in animal cells. We have discovered a broad family of cGAS-like nucleotidyltransferases in bacteria that use both purine and pyrimidine nucleotides to synthesize an exceptionally diverse range of CDNs. Biochemical and cellular analysis of novel nucleotide second messengers demonstrate that these signals activate distinct host receptors and thus may modulate the interaction of both pathogenic and commensal microbiota with their animal and plant hosts.