University of Dundee

"Wnt signaling pathways and the regulation of axial progenitors"

Event Date: 
Thursday, June 20, 2019 - 14:00 to 15:00
Event Location: 
CTIR Sir Kenneth and Lady Noreen Murray Seminar Room
Host: 
Professor Kate Storey FRSE FMedSci FRSB
Event Speaker: 
Dr Terry Yamaguchi
Institution: 
Centre for Cancer Research, National Cancer Institute Bethesda, Maryland
Event Type: 
Seminar
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The Yamaguchi laboratory is studying how the Wnt family of signaling molecules regulates the formation of the mammalian body plan. We are focused on neuromesodermal progenitors (NMPs), a population of embryonic cells that give rise to the spinal cord and musculoskeletal cells of the mammalian trunk and tail. Wnts are secreted by the primitive streak during gastrulation and induce NMPs from the adjacent pluripotent epiblast however the underlying mechanisms remain unclear. We are particularly interested in understanding how Wnts induce NMP fate from the pluripotent epiblast, how gene regulatory networks control cell fate selection, and how the neck, trunk and tail are uniquely specified. I will focus on the roles that several transcription factors play in the regulation of these processes.