University of Dundee

Adam Neville Lecture 2019 - ‘Sensing infection and tissue damage’

Event Date: 
Friday, May 3, 2019 - 13:00 to 14:00
Event Location: 
MSI Large Lecture Theatre
Host: 
Professor Claire Halpin FRSE FRSB
Event Speaker: 
Professor Caetano Reis e Sousa
Institution: 
Immunobiology Laboratory, The Francis Crick Institute
Event Type: 
Named Lecture
Share

The talk will be followed by a refreshments in WTB Life Space, to which everyone is invited. 

 

Abstract 

Innate and adaptive immunity work concertedly in vertebrates to restore homeostasis following pathogen invasion or other insults. Like all homeostatic circuits, immunity relies on an integrated system of sensors, transducers and effectors that can be analysed in cellular or molecular terms. At the cellular level, T and B lymphocytes act as an effector arm of immunity that is mobilised in response to signals transduced by innate immune cells that detect a given insult. These innate cells are spread around the body and include dendritic cells (DCs), the chief immune sensors of pathogen invasion and tumour growth. At the molecular level, DCs possess receptors that directly sense pathogen presence and tissue damage and that signal via transduction pathways to control antigen presentation or regulate a plethora of genes encoding effector proteins that regulate immunity. Understanding how DCs integrate environmental signals to drive immunity to infection and cancer expands our knowledge of immune processes and has important applications in vaccination and immunotherapy.

 

About the lecture series:

Adam Neville was the Principal of the University of Dundee from 1978-1987. This lecture series was set up in recognition of Adam Neville’s key role in ensuring the survival of the Department of Biochemistry in the late 1970s at a time when its financial position was extremely precarious. This is one of SLS’s most prestigious named lectures.