University of Dundee

"Genomic instability and “escape” from oncogene-induced senescence"

Event Date: 
Wednesday, December 4, 2019 - 13:00
Event Location: 
Tanis Drummond, Lecture Theatre, Ninewells Hospital and Medical School
Event Speaker: 
Konstantinos Evangelou
Institution: 
Associate Professor, Department of Histology, Medical School, National and Kapodistrian University of Athens
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Event Type: 
Seminar

Abstract:             Oncogene-induced senescence is considered an important tumor suppressor mechanism. Yet, if not removed timely by the immune surveillance system it will present a detrimental side. Though the latter is attributed to the so called senescence-associated-secretory-phenotype (SASP), recent reports demonstrate that “escape” from senescence may represent another unfavourable outcome. Herein, we present evidence that oncogene-induced DNA damage, occurring from the early phases of senescence, forms a driving force participating in the “escape” phenotype. Within this frame we also present an in silico pipeline that discriminates driver from passenger genetic events linked with drug responsiveness.

 

Email signatureKey recent papers :

 

GORGOULIS V, ADAMS PD, ALIMONTI A, BENNETT DC, BISCHOF O, BISHOP C, CAMPISI J, COLLADO M, EVANGELOU K, FERBEYRE G, GIL J, HARA E, KRIZHANOVSKY V, JURK D, MAIER AB, NARITA M, NIEDERNHOFER L, PASSOS JF, ROBBINS PD, SCHMITT CA, SEDIVY J, VOUGAS K, VON ZGLINICKI T, ZHOU D, SERRANO M, DEMARIA M. Cellular Senescence: Defining a Path Forward. Cell. 2019 Oct 31;179(4):813-827. doi: 10.1016/j.cell.2019.10.005.

 

Vougas K, Sakelaropoulos T, Kotsinas A, Foukas GP, Ntargaras A, Koinis F, Polyzos A, Myrianthopoulos V, Zhou H, Narang S, Georgoulias V, Alexopoulos L, Aifantis I, Townsend PA, Sfikakis P, Fitzgerald R, Thanos D, Bartek J, Petty R, Tsirigos A, Gorgoulis VG.Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining. Pharmacol Ther. 2019 30:107395.

 

 

BERGDOLT L*, NANDA I*, EVANGELOU K*, NIKOLOVA T *, HORN V*, SAGAR M, ERNY D, STEFANOWSKI J, ROGELL L, KLEIN C, GHARUN K, FOLLO M, KREMER B, SEIDL M, MÜNKE N, SANGER J, FLIEGAUF Μ, ASCHMAN T, PFEIFER D, SARRAZIN S, SIEWEKE M, WAGNER D, DIERKS C, HAAF T, NESS T, ZAISSM, REINHARD V, DESHMUKH S, PRINZ M, GOLDMANN T, HÖLSCHER C, HAUSER A, LOPEZ-CONTRERAS AJ, GRÜN D, GORGOULIS V, DIEFENBACH A, HENNEKE P, TRIANTAFYLLOPOULOU A. DNA damage signaling instructs polyploid macrophage fate in granulomas. Cell. 2016 Nov;167(5):1264–1280 (*equal contribution)

 

EVANGELOU K*, LOUGIAKIS N*, RIZOU SV, KOTSINAS A, KLETSAS D, MUÑOZ ESPÍN D, KASTRINAKIS N, POULI N, MARAKOS P, TOWNSEND P, SERRANO M, BARTEK J, GORGOULIS VG. Robust, universal biomarker assay to detect senescent cells in biological specimens. Aging Cell. 2017 Feb; 16(1):192-197. (*equal contribution)

 

More information at:

https://www.gorgoulis.gr/team/current-team/42-collaborators/54-konstantinos-evangelou

https://scholar.google.gr/citations?user=Y4QTQFYAAAAJ&hl=el