University of Dundee

"Bioinformatics and Disease - from mutations to antibodies"

Event Date: 
Friday, February 21, 2020 - 11:00
Event Location: 
School of Life Sciences, MSI Small Lecture Theatre
Host: 
Professor Geoff Barton FRSE FRSB
Event Speaker: 
Professor Andrew Martin,
Institution: 
Institute of Structural and Molecular Biology, UCL
Event Type: 
Seminar
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We work primarily in two areas: understanding the effects of mutations on protein structure and disease; and the use of antibodies as drugs. We have developed tools for analyzing the local structural effects of single amino acid changes and built a predictor to assess whether these are likely to lead to disease. In addition, we have built a specialized predictor for mutations in cardiac beta mysosin which is able to classify whether mutations lead to one of two different phenotypes - hypertrophic cardiomyopathy or dilated cardiomyopathy.  These tools can be applied to the understanding of genetic disease and the identification of novel mutations likely to cause disease can encourage control through life-style changes or early intervention. Over the last 10 years, antibodies have become phenomenally successful as a route to intervene in many diseases from

high cholesterol through migraine and rheumatoid arthritis to cancer.  We have developed databases and tools to enable the development of successful antibody-based drugs. These are widely used over the web and a number of companies now also used them in house.