"Integrating Heat Shock Molecular Chaperones into the Histone Chaperone Network"
Tuesday, April 27, 2021 - 13:00 to 14:00
NNF CPR - Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
Abstract: Through the integration of structure-guided and functional proteomic assays we have identified and characterised a protein that encodes both histone chaperone and heat shock co-chaperone functionalities. My talk will describe our in-depth functional analysis of this novel link between the histone chaperone and heat shock molecular chaperone worlds. This work reveals a surprising continuous need for heat shock catalysis to interface with histone chaperone biology. Heat shock biology impacts many cellular processes and when combined with the multidisciplinary nature of our work I hope this seminar will appeal to a broad audience.