University of Dundee

FMN2 update published in Cell Cycle

18 Jul 2013

 

In a new paper entitled “FMN2 is a novel regulator of the cyclin dependent kinase inhibitor p21”, published in the journal Cell Cycle, the Lamond and Rocha groups further analysed the role of FMN2 in the important tumour suppressor pathway mediated by p14ARF and p53. This study extends the findings published earlier this year in Molecular Cell. Using a combination of imaging, proteomic and biochemical analysis, our new data indicates that the N-terminal part of the FMN2 protein, is the most important functional region of the molecule for the control of the p21 cell cycle inhibitor. Our combined studies reveal that FMN2 is a potential biomarker for proliferative disorders and could be a future target for therapy.

 

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