Latest News for 06/2020
12 Apr 2018
Dr Virdee and colleagues in the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) have discovered a novel class of E3 ligase. The E3 ligase, MYCBP2, operates in a unique way, selectively transferring ubiquitin to non-lysine amino acids with selectivity for threonine. The ubiquitin is linked to the threonine amino acid via a chemically distinct ester linkage thereby uncovering an unanticipated area of cellular biology. The findings are published in Nature.
16 Mar 2017
The School of Life Sciences Prizes were presented today at the Research Symposium in Crieff. Each of the judging panels commented on the high standard and quality of the entries submitted which exemplifies the research excellence and outstanding public engagement taking place in the School.
01 Jul 2016
Researchers in the laboratory of Dr. Satpal Virdee have published the first example of genetically encodable aminooxy functionality, which can be installed site-selectively into recombinant proteins using genetic code expansion technology. The findings were published in Chembiochem this week.
30 Jun 2016
Satpal Virdee has been awarded a BBSRC Responsive Mode award of £650,000 allowing his lab to further develop technology they pioneered that enables the activity-based profiling of E3 ligases.
07 Mar 2016
Pioneering chemical technology developed at the University of Dundee is giving scientists the clearest insight yet into crucial biochemical processes that are active in many diseases, including Parkinson’s disease. Dr Satpal Virdee, leader of the research team, said their findings could `revolutionise’ research capability. Already the Dundee team have used their newly developed tools to make new discoveries relating to the activity of the Parkin enzyme, which when mutated is a cause of Parkinson’s disease.