University of Dundee

Wellcome 4-Year PhD Programme in Integrated Molecular, Cellular and Translational Biology

The Wellcome Trust Integrated molecular, cellular and translational biology programme combines scientific excellence with a commitment to improving the working environment and transition support for trainees. This PhD programme, provided by world-renowned scientists from the School of Life Sciences at the University of Dundee, will train the next generation of scientists at the forefront of international science. Students will join our supportive and positive research culture with the opportunity to select research projects centred around four themes:

  1. Cellular Regulation
  2. Protein Modification
  3. Infection and Immunity
  4. Drug Discovery and Translation

Around 50 different potential supervisors will participate in this programme

Prof Philip Cohen

My research focuses on how the innate immune system is regulated by the interplay between protein phosphorylation and protein ubiquitylation events. Major ongoing projects include understanding how the E3 ubiquitin ligase TRAF6 prevents the uncontrolled activation of T cells to prevent autoimmunity, and how the ubiquitin-binding protein ABIN1 restricts Toll-Like Receptor signalling pathways to prevent lupus. Following our recent discovery that the E3 ligase HOIL-1 forms unique ester bonds between ubiquitin and its target proteins, we are studying the role of HOIL-1 in controlling innate immunity and other biological processes.  Another major project is to understand how the SIK subfamily of protein kinases control cytokine production in mast cells and we are evaluating their potential as drug targets for the treatment of asthma and other diseases, in collaboration with Simon Arthur.

https://www.lifesci.dundee.ac.uk/phdprog/supervisors