The MRC Protein Phosphorylation and Ubiquitylation Unit (PPU) is a major research centre that focuses on the understanding of the biological roles of phosphorylation and ubiquitylation and how disruption of these processes cause human diseases such as neurodegeneration, cancer, hypertension and immune disorders. The ultimate goal of the Unit’s research programmes is to help develop new improved strategies to treat disease. The MRC-PPU operates as a focal point between life scientists, pharmaceutical companies and clinicians to ensure that we make a critical contribution to medical research, together reaching a deeper understanding of disease.
Medical Research Council Protein Phosphorylation and Ubiquitylation Unit
Principal Investigators
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Professor Dario Alessi FRS FRSE Professor of Signal Transduction and Director of MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU) and the Division of Signal Transduction Therapy Unit (DSTT) Understanding signalling pathways mutated in inherited disorders |
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Professor Sir Philip Cohen FRS FRSE FMedSci Professor of Enzymology and Co-Director of the Division of Signal Transduction Therapy (DSTT) Signaling Networks that Regulate the Innate Immune System |
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Dr Ian Ganley Programme Leader Molecular analysis of autophagy |
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Dr. Yogesh Kulathu Programme Leader Ubiquitin signalling mechanisms |
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Professor Karim Labib FRSE Professor of Genome Integrity Roles and regulation of the eukaryotic replisome in preserving genome integrity and epigenetics |
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Professor Miratul Muqit Wellcome Trust Senior Research Fellowship in Clinical Science and Programme Leader Elucidation of the PINK1 signaling pathway in Parkinson’s disease |
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Professor John Rouse FRSE Programme Leader in Protein Phosphorylation Control of chromosome stability and DNA repair in health and disease |
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Dr Gopal Sapkota Programme Leader in Protein Phosphorylation Untangling the TGFβ and Wnt signalling networks in cells, development and human diseases |
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Dr. Mahima Swamy Wellcome Trust and Royal Society Sir Henry Dale Fellow Immune interactions at the intestinal epithelium |
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Dr Satpal Virdee Programme Leader in Protein Ubiquitylation Chemical Biology Approaches for Studying The Ubiquitin System |
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Dr Greg Findlay Programme Leader MRC Protein Phosphorylation and Ubiquitylation Unit Embryonic Stem Cell Signaling Modules |
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Dr Adrien Rousseau Principal Investigator |