University of Dundee

Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

The MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) is  a major research centre that focuses on the understanding of the biological roles of  phosphorylation and ubiquitylation and how disruption of these processes cause human diseases such as neurodegeneration, cancer, hypertension and immune disorders. The ultimate goal of the Unit’s research programmes is to help develop new improved strategies to treat disease. The MRC-PPU operates as a focal point between life scientists, pharmaceutical companies and clinicians to ensure that we make a critical contribution to medical research, together reaching a deeper understanding of disease.

Principal Investigators

Professor Dario Alessi FRS FRSE FMedSci
Professor of Signal Transduction and Director of MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU) and the Division of Signal Transduction Therapy Unit (DSTT)
Understanding signalling pathways mutated in inherited disorders
Professor Sir Philip Cohen FRS FRSE FAA FFMedSci
Professor of Enzymology
Signaling Networks in the Innate Immune System
Dr Ian Ganley
Programme Leader
Molecular analysis of autophagy
Dr. Yogesh Kulathu
Programme Leader
Ubiquitin signalling mechanisms
Professor Karim Labib FRSE
Professor of Genome Integrity
Chromosome replication and genome integrity
Professor Miratul Muqit FRSE
Wellcome Trust Senior Research Fellowship in Clinical Science, Programme Leader and Professor of Experimental Neurology
Elucidation of the PINK1 signaling pathway in Parkinson’s disease
Professor John Rouse FRSE
Programme Leader in Protein Phosphorylation and Professor of Chromosome Biology
Control of chromosome stability and DNA repair in health and disease
Professor Gopal Sapkota
Programme Leader in Protein Phosphorylation and Professor of Disease Signalling
Untangling the TGFβ and Wnt signalling networks in cells, development and human diseases
Dr. Mahima Swamy
Wellcome Trust and Royal Society Sir Henry Dale Fellow
Immune interactions at the intestinal epithelium
Professor Satpal Virdee
Programme Leader in Protein Ubiquitylation and Professor of Chemical Biology
Chemical Biology Approaches for Studying The Ubiquitin System
Dr Greg Findlay
Programme Leader MRC Protein Phosphorylation and Ubiquitylation Unit
Embryonic Stem Cell Signaling Modules
Dr Adrien Rousseau
Principal Investigator
Kirby Swatek
Principal Investigator


Professor Kim Dale FRSB
Assistant Vice Principal International, Associate Dean (International) and Professor of Molecular Developmental Biology
Establishing the vertebrate embryonic body plan
Dr Sheriar Hormuzdi
Senior Lecturer (Teaching and Scholarship) and Programme Lead (Biological Sciences)

Independent Investigators

Dr. Virginia De Cesare
Independent Investigator and UKRI Future Leaders Fellow