University of Dundee


Baragaña, B, Forte, B, Choi, R, Nakazawa Hewitt, S, Bueren-Calabuig, JA, Pisco, JP, Peet, C, Dranow, DM, Robinson, DA, Jansen, C, Norcross, NR, Vinayak, S, Anderson, M, Brooks, CF, Cooper, CA, Damerow, S, Delves, M, Dowers, K, Duffy, J, Edwards, TE, Hallyburton, I, Horst, BG, Hulverson, MA, Ferguson, L, Jiménez-Díaz, MB, Jumani, RS, Lorimer, DD, Love, MS, Maher, S, Matthews, H, McNamara, CW, Miller, P, O'Neill, S, Ojo, KK, Osuna-Cabello, M, Pinto, E, Post, J , Riley, J, Rottmann, M, Sanz, LM, Scullion, P, Sharma, A, Shepherd, SM, Shishikura, Y, Simeons, FRC, Stebbins, EE, Stojanovski, L, Straschil, U, Tamaki, FK, Tamjar, J, Torrie, LS, Vantaux, A, Witkowski, B, Wittlin, S, Yogavel, M, Zuccotto, F, Angulo-Barturen, I, Sinden, R, Baum, J, Gamo, F-J, Mäser, P, Kyle, DE, Winzeler, EA, Myler, PJ, Wyatt, PG, Floyd, D, Matthews, D, Sharma, A, Striepen, B, Huston, CD, Gray, DW, Fairlamb, AH, Pisliakov, AV, Walpole, C, Read, KD, Van Voorhis, WC & Gilbert, IH 2019, 'Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis' Proceedings of the National Academy of Sciences, vol. 116, no. 14, pp. 7015-7020.

Bell, M, Foley, D, Naylor, C, Wood, G, Robinson, C, Riley, J, Epemolu, R, Ellis, L, Scullion, S, Shishikura, Y, OsunaCabello, M, Ferguson, L, Pinto, E, Fletcher, D, Katz, E, McLean, W, Wyatt, P, Read, K & Woodland, C 2019, 'Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)' ACS Medicinal Chemistry Letters, vol. 10, no. 3, pp. 341–347.

Bueno, R, Dawson, A & Hunter, WN 2019, 'An assessment of three human methylenetetrahydrofolate dehydrogenase/cyclohydrolase-ligand complexes following further refinement' Acta Crystallographica Section F: Structural Biology Communications, vol. 75, no. Pt 3, pp. 148-152.

Castro, GVD & Ciulli, A 2019, 'Spy vs. Spy: Selecting the best reporter for 19F NMR competition experiment' Chemical Communications, vol. 55, no. 10, pp. 1482-1485.

Collett, CF, Kitson, C, Baker, N, Steele-Stallard, HB, Santrot, M-V, Hutchinson, S, Horn, D & Alsford, S 2019, ' Chemogenomic profiling of anti-leishmanial efficacy and resistance in the related kinetoplastid parasite Trypanosoma brucei' Antimicrobial Agents and Chemotherapy.

Corpas Lopez, V, Moniz, S, Thomas, M, Wall, R, Torrie, L, Zander-Dinse, D, Tinti, M, Brand, S, Stojanovski, L, Manthri, S, Hallyburton, I, Zuccotto, F, Wyatt, P, De Rycker, M, Horn, D, Ferguson, M, Clos, J, Read, K, Fairlamb, A, Gilbert, I & Wyllie, S 2019, 'Pharmacological validation of N-myristoyltransferase as a drug target in Leishmania donovani' ACS Infectious Diseases, vol. 5, no. 1, pp. 111-122.

Correia Faria, J, Glover, L, Hutchinson, S, Boehm, C, Field, M & Horn, D 2019, 'Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex' Nature Communications.

Ebenezer, T, Zoltner, M, Burrell, A, Nenarokova, A, Novák Vanclová, AMG, Prasad, B, Soukal, P, Santana-Molina, C, O'Neill, E, Nankissoor, NN, Vadakedath, N, Daiker, V, Obado, S, Silva-Pereira, S, Jackson, AP, Devos, DP, Lukeš, J, Lebert, M, Vaughan, S, Hampl, V, Carrington, M, Ginger, ML, Dacks, JB, Kelly, S & Field, M 2019, 'Transcriptome, proteome and draft genome of Euglena gracilis' BMC Biology, vol. 17, 11, pp. 1-23. 0626-8

Elhaji, Y, Sasseville, D, Pratt, M, Asai, Y, Matheson, K, McLean, WHI & Hull, P 2019, 'Filaggrin gene loss-of-function mutations constitute a factor in patients with multiple contact allergies' Contact Dermatitis.

Fersing, C, Basmaciyan, L, Boudot, C, Pedron, J, Hutter, S, Cohen, A, Castera-Ducros, C, Primas, N, Laget, M, Casanova, M, Bourgeade-Delmas, S, Piednoel, M, Sournia-Saquet, A, Belle Mbou, V, Courtioux, B, Boutet-Robinet, É, Since, M, Milne, R, Wyllie, S, Fairlamb, AH, Valentin, A, Rathelot, P, Verhaeghe, P, Vanelle, P & Azas, N 2019, ' Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity' ACS Medicinal Chemistry Letters, vol. 10, no. 1, pp. 34-39.

Field, MC & Rout, MP 2019, 'Pore timing: the evolutionary origins of the nucleus and nuclear pore complex' F1000Research, vol. 8, 369, pp. 1-11.

Field, MC 2019, 'The kinetochore and the origin of eukaryotic chromosome segregation' Proceedings of the National Academy of Sciences of the United States of America.

Ford, GA, Lord, JM, Ferguson, MAJ, Bountra, C & Le Couteur, DG 2019, 'Organizational innovation for developing new medicines that target aging and age-related conditions' The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, pp. 1-4.

Frost, J, Ciulli, A & Rocha, S 2019, 'RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response' Wellcome Open Research, vol. 4, 17, pp. 1-17.

Girardini, M, Maniaci, C, Hughes, S, Testa, A & Ciulli, A 2019, 'Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs' Bioorganic & Medicinal Chemistry.

Gottschald Chiodi, C, Baptista-Hon, D, Hunter, W & Hales, T 2019, 'Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA' Journal of Biological Chemistry, vol. 294, no. 7, pp. 2375-2385.

Kung, W-W, Ramachandran, S, Makukhin, N, Bruno, E & Ciulli, A 2019, 'Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase' Nature Communications.

Luise, N, Wyatt, EW, Tarver, G & Wyatt, P 2019, 'A Continuous Flow Strategy for the Facile Synthesis and Elaboration of Semi-Saturated Heterobicyclic Fragments' European Journal of Organic Chemistry, vol. 2019, no. 6, pp. 1341-1349.

Martin, J, Mackenzie, C, Fletcher, D & Gilbert, I 2019, 'Characterising Covalent Warhead Reactivity' Bioorganic & Medicinal Chemistry, vol. 27, no. 10, pp. 2066-2076.

Mattos, EC, Canuto, G, Varón, NCM, Magalhães, RDM, Crozier, TWM, Lamont, DJ, Tavares, MFM, Colli, W, Ferguson, MAJ & Alves, MJM 2019, 'Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix' PLoS Neglected Tropical Diseases, vol. 13, no. 2, e0007103, pp. 1-27.

Moitra, S, Pawlowic, MC, Hsu, F-F & Zhang, K 2019, 'Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major' Scientific Reports, vol. 9, 7602, pp. 1-13.

Pankov, G, Dawson, A & Hunter, WN 2019, 'The structure of lipopolysaccharide transport protein B (LptB) from Burkholderia pseudomallei' Acta Crystallographica Section F: Structural Biology Communications, vol. 75, no. 4, pp. 227- 232.

Popow, J, Arnhof, H, Bader, G, Berger, H, Ciulli, A, Covini, D, Dank, C, Gmaschitz, T, Greb, P, Karolyi-Özguer, J, Koegl, M, McConnell, DB, Pearson, M, Rieger, M, Rinnenthal, J, Roessler, V, Schrenk, A, Spina, M, Steurer, S, Trainor, N, Traxler, E, Wieshofer, C, Zoephel, A & Ettmayer, P 2019, 'Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions' Journal of Medicinal Chemistry, vol. 62, no. 5, pp. 2508–2520.

Prakash, O, Führing, J, Post, J, Shepherd, SM, Eadsforth, TC, Gray, D, Fedorov, R & Routier, FH 2019, 'Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening' Molecules and Cells, vol. 24, no. 5, 996, pp. 1-16.

Roy, M, Winkler, S, Hughes, SJ, Whitworth, C, Galant, M, Farnaby, W, Rumpel, K & Ciulli, A 2019, 'SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate' ACS Chemical Biology, vol. 14, no. 3, pp. 361-368.

Thomas, MG, De Rycker, M, Ajakane, M, Albrecht, S, Álvarez-Pedraglio, AI, Boesche, M, Brand, S, Campbell, L, Cantizani-Perez, J, Cleghorn, LAT, Copley, RCB, Crouch, SD, Daugan, A, Drewes, G, Ferrer, S, Ghidelli-Disse, S, Gonzalez, S, Gresham, SL, Hill, AP, Hindley, SJ, Lowe, RM, MacKenzie, CJ, MacLean, L, Manthri, S, Martin, F, MiguelSiles, J, Nguyen, VL, Norval, S, Osuna-Cabello, M, Woodland, A, Patterson, S, Pena, I, Quesada-Campos, MT, Reid, IH, Revill, C, Riley, J, Ruiz-Gomez, JR, Shishikura, Y, Simeons, FRC, Smith, A, Smith, VC, Spinks, D, Stojanovski, L, Thomas, J, Thompson, S, Underwood, T, Gray, DW, Fiandor, JM, Gilbert, IH, Wyatt, PG, Read, KD & Miles, TJ 2019, ' Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis' Journal of Medicinal Chemistry, vol. 62, no. 3, pp. 1180-1202.

Torrie, L, Zuccotto, F, Robinson, D, Gray, D, Gilbert, I & De Rycker, M 2019, 'Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase' PLoS ONE.

Tovell, H, Testa, A, Maniaci, C, Zhou, H, Prescott, A, Macartney, T, Ciulli, A & Alessi, D 2019, 'Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader' ACS Chemical Biology , vol. 14, no. 5, pp. 882-892.

Trenaman, A, Glover, L, Hutchinson, S & Horn, D 2019, 'A post-transcriptional respiratome regulon in trypanosomes' Nucleic Acids Research.

Velasco, RF, Guerrero, C, Fra, G, Moure, A, Miguel-Siles, J, Quesada-Campos, MT, Ruiz-Gomez, JR, Gilbert, IH, Thomas, MG & Miles, TJ 2019, 'Optimisation of a Key Cross-Coupling Reaction Towards the Synthesis of a Promising Antileishmanial Compound' Tetrahedron Letters, vol. 60, no. 18, pp. 1243-1247.

Wyllie, S, Brand, S, Thomas, M, De Rycker, M, Chung, C-W, Peña, I, Bingham, R, Bueren-Calabuig, J, Cantizani, J, Cebrian, D, Craggs, PD, Ferguson, L, Goswami, P, Hobrath, J, Howe, J, Jeacock, L, Ko, EJ, Korczynska, J, MacLean, L, Manthri, S, Santos Martinez, M, Mata-Cantero, L, Moniz, S, Nuhs, A, Osuna-Cabello, M, Pinto, E, Riley, J, Robinson, S, Rowland, P, Simeons, F, Shishikura, Y, Spinks, D, Stojanovski, L, Thomas, J, Thompson, S, Viayna Gaza, E, Wall, R, Zuccotto, F, Horn, D, Ferguson, M, Fairlamb, A, Fiandor, JM, Martín, J, Gray, D, Miles, TJ, Gilbert, I, Read, K, Marco, M & Wyatt, P 2019, 'Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition' Proceedings of the National Academy of Sciences, vol. 116, no. 19, 201820175, pp. 9318-9323.,

EAT Study Team, Marrs, T, Logan, K, Craven, J, Radulovic, S, McLean, WHAI, Lack, G, Flohr, C & Perkin, MR 2019, ' Dog ownership at three months of age is associated with protection against food allergy' Allergy.