Research in the Centre for Systems Biology is directed towards a quantitative understanding of biological systems at all levels of complexity and the interactions between them. It is geared towards understanding the design principles and emergent properties of complex multi-component systems that define and control their function and organisation. Insights obtained will be essential to our in depth understanding of the genotype to phenotype transition in microorganisms, plants and animals, the functioning of organisms in their normal and diseased states and the development of a predictive and personalised medicine. Research in the Centre is highly interdisciplinary, many groups are located in the College of Life Sciences but there exist strong and rapidly expanding interdisciplinary interactions with groups in the College of Art Science and Engineering, especially in Computing, Mathematics and Physics.
- Geoff Barton - Development of computational/mathematical methods to understand biological systems.
- Mikael Bjorklund - Systems biology of cell growth in Drosophila and human cell culture models.
- Julian Blow - Systems biology approaches to the cell cycle control of DNA replication.
- Paul Campbell - Optimisation of drug delivery processes by ultrasound and lasers
- Mark Chaplain - Multiscale analysis of cancer growth and Angiogenesis.
- Mike Ferguson - The Systems Biology of Post-Translational Modifications in Trypanosomatid Parasites
- Geoff Gadd/ Fordyce Davidson - Multiscale analysis of growth and morphogenesis in filamentous fungi.
- Ron Hay - System wide analysis of SUMO conjugation in response to stress.
- Angus Lamond - Proteomes in Time & Space - The Systems Biology of Human Nuclear Proteins
- Carol MacKintosh - 14-3-3 mediated cellular responses to growth factors, nutrients and exercise.
- David Martin - Analysis of Phosphoproteome data and sequence analysis of the Potato Genome.
- Tom Owen-Hughes - Combined genomic approaches to study chromatin structure and gene regulation.
- Jason Swedlow - Fundamental mechanisms of chromosome segregation in mitosis in human cells
- Tomo Tanaka - Chromosome duplication and segregation in the cell division cycle
- Daan van Aalten - The interplay of protein phosphorylation / O-GlcNAcylation in signalling systems
- Kees Weijer - Control of cell movement during Dictyostelium development and gastrulation.
