University of Dundee

Biological Chemistry and Drug Discovery

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PROTACs go macrocyclic

Researchers in the Ciulli group report a first study describing the idea of a macrocyclic PROTAC. The research was published in the prestigious chemistry journal Angewandte Chemie.

PROTACs (for proteolysis-targeting chimeras) are double-headed molecules composed of a ligand for a target protein and a ligand for an E3 ubiquitin ligase, chemically joined by a flexible linker. The PROTAC simultaneously recruits the target protein and the E3 ligase into close proximity, and this leads to the target protein being destroyed inside the cell.

Postdoctoral Research Assistant

The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

Postdoctoral Research Assistant

We are looking for a highly motivated researcher with appropriate skills in molecular and cell biology to work on our project ‘Gene editing in parasites for target validation and screening’. The project is funded by The Wellcome Trust and a major goal is to understand drug targets in parasitic trypanosomatids (Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani).

The post is available full-time for 2.25 years and salary will depend on experience, but will be up to £40,322.

CSC - Decoding gene expression mechanisms in trypanosomes

The African trypanosome, Trypanosoma brucei, is transmitted among mammalian hosts by tsetse flies. These unicellular parasites cause sleeping sickness, also known as Human African Trypanosomiasis, which is typically fatal if left untreated, and the livestock disease known as nagana. Molecular mechanisms underlying antigenic variation and gene expression control remain to be fully characterized.