Biological Chemistry and Drug Discovery
The Wellcome Centre for Anti-Infectives Research (WCAIR) was created in April 2017. Based within the School of Life Sciences, University of Dundee, and incorporating the world-leading Drug Discovery Unit, WCAIR leads in innovation to accelerate drug discovery for diseases of the developing world such as malaria, tuberculosis, leishmaniasis and Chagas disease (www.wcair.dundee.ac.uk).
Bifunctional degrader molecules also known as Proteolysis Targeting Chimeras (PROTACs) and the mechanistically related monovalent degraders (for example auxin, lenalidomide and indisulam) work by co-opting an E3 ubiquitin ligase to act upon a neo-substrate protein. Formation of a ternary complex species between the E3 ligase, the degrader molecule and the target protein leads to the latter being ubiquitinated and subsequently degraded by the proteasome.
Two Life Sciences academics who are helping transform lives with their work on major diseases including Parkinson’s and neglected tropical diseases such as malaria have been elected Fellows of the Royal Society of Edinburgh (RSE).
The RSE is Scotland’s national academy, focused on delivering its mission of `knowledge made useful’. Fellows are elected in recognition of their impact in improving the world around them.
Wellcome Centre for Anti-Infectives Research
We are looking for a highly motivated researcher with appropriate skills in molecular and cell biology to work on ‘Decoding gene regulation mechanisms in the African trypanosome’. The project is funded by The Wellcome Trust and a major goal is to understand gene expression mechanisms in African trypanosomes (see http://www.lifesci.dundee.ac.uk/groups/david-horn).
Summary of Job Purpose and Principal Duties
Dr Robyn Hickerson’s laboratory is seeking a postdoctoral researcher to undertake research in collaboration with WAVE Lifesciences towards developing topical delivery methods to effectively treat genetic skin disorders with antisense oligonucleotides.