We are looking for a Postdoctoral Research Assistant to join us at the Victoria Cowling lab, Centre for Gene Regulation and Expression, University of Dundee. The postdoc will be part of the team investigating the impact of mRNA cap regulation on T cell gene expression and cell fate decisions.
Centre for Gene Regulation and Expression
New research by Greg Findlay’s group in the MRC-PPU has identified a signalling system that controls embryonic stem cell development, which has implications for understanding how tissues form within the mammalian embryo. The paper, by Rosalia Fernandez-Alonso and Francisco Bustos, post-doctoral investigators in Greg’s lab, uncovers a new role for the EPH-Ephrin system in regulating stem cell differentiation.
This week forty researchers completed a two-day workshop in Cryo Electron Microscopy (EM) held in the School. Cryo EM makes it possible to see the biological molecules that underpin life in atomic detail. Participants from Dundee and St Andrews benefited from lectures and practical workshops given by experts from across the UK including:
Bifunctional degrader molecules also known as Proteolysis Targeting Chimeras (PROTACs) and the mechanistically related monovalent degraders (for example auxin, lenalidomide and indisulam) work by co-opting an E3 ubiquitin ligase to act upon a neo-substrate protein. Formation of a ternary complex species between the E3 ligase, the degrader molecule and the target protein leads to the latter being ubiquitinated and subsequently degraded by the proteasome.
Professors Vicky Cowling and Tomo Tanaka were given Investigator Awards from Wellcome in the recent funding round. Vicky’s award of £1.3M will allow her to take her expertise on mRNA cap regulation in a new direction while Tomo’s award of ~£1.5M will allow him to continue to build new knowledge on the process of cell division. This will fund their programmes of research for 5 years.
Researchers in the School of Life Sciences at the University of Dundee have helped to uncover and understand the genome of a vitally important orphan crop, called water yam.
A study published this week in the journal eLife, by a team at University of Dundee's School of Life Sciences uses a new approach to reveal the complexity and modifications of RNA that are essential to genetic control. They passed RNA through pores developed by Oxford Nanopore Technology to reveal directly the sequence of 1000s of RNA molecules.
The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high-quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.