University of Dundee

Centre for Gene Regulation and Expression

Short Code: 
GRE

Findlay lab makes new insights into tissue development from stem cells

New research by Greg Findlay’s group in the MRC-PPU has identified a signalling system that controls embryonic stem cell development, which has implications for understanding how tissues form within the mammalian embryo. The paper, by Rosalia Fernandez-Alonso and Francisco Bustos, post-doctoral investigators in Greg’s lab, uncovers a new role for the EPH-Ephrin system in regulating stem cell differentiation.

Cryo EM Workshop held in School

This week forty researchers completed a two-day workshop in Cryo Electron Microscopy (EM) held in the School. Cryo EM makes it possible to see the biological molecules that underpin life in atomic detail. Participants from Dundee and St Andrews benefited from lectures and practical workshops given by experts from across the UK including:

MRC DTP iCASE PhD Project: Developing novel biophysical and cellular assays to study small-molecule mediated protein ubiquitination and degradation

Bifunctional degrader molecules also known as Proteolysis Targeting Chimeras (PROTACs) and the mechanistically related monovalent degraders (for example auxin, lenalidomide and indisulam) work by co-opting an E3 ubiquitin ligase to act upon a neo-substrate protein. Formation of a ternary complex species between the E3 ligase, the degrader molecule and the target protein leads to the latter being ubiquitinated and subsequently degraded by the proteasome.

Wellcome Investigator Awards for GRE researchers

Professors Vicky Cowling and Tomo Tanaka were given Investigator Awards from Wellcome in the recent funding round. Vicky’s award of £1.3M will allow her to take her expertise on mRNA cap regulation in a new direction while Tomo’s award of ~£1.5M will allow him to continue to build new knowledge on the process of cell division. This will fund their programmes of research for 5 years.

A new approach to revealing the complexity of RNAs that genomes really encode

A study published this week in the journal eLife, by a team at University of Dundee's School of Life Sciences uses a new approach to reveal the complexity and modifications of RNA that are essential to genetic control. They passed RNA through pores developed by Oxford Nanopore Technology to reveal directly the sequence of 1000s of RNA molecules.

Principal Investigators in Genome dynamics

The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high-quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

Pages