University of Dundee

Centre for Gene Regulation and Expression

Short Code: 
GRE

‘Biophysical basis of cellular multi-specificity encoded in a model molecular switch - How does a small GTPase Ran/Gsp1 regulate multiple cellular processes’

Tina graduated from University of Zagreb with a degree in Molecular Biology during which she worked in Ivan Dikic's lab as an undergraduate. Tina did her PhD at MRC-LMB with Sarah Teichmann, working together with Cyrus Chothia and Jane Clarke on the evolution of protein complexes.

Cunningham Trust PhD Studentship: Fishing up human chromosomes in early mitosis – a novel mechanism preventing chromosome instability

Professor Tomo Tanaka is inviting applications from bright and enthusiastic graduates for a fully-funded 3-year PhD studentship. The studentship is supported by the Cunningham Trust and will start in September 2020. The Tanaka lab is based at the Centre for Gene Regulation and Expression within the School of Life Sciences at the University of Dundee, UK (https://tomotanakalab.weebly.com). His group has been studying mechanisms of high-fidelity chromosome segregation in mitosis.

"Genomic instability and “escape” from oncogene-induced senescence"

Abstract:             Oncogene-induced senescence is considered an important tumor suppressor mechanism. Yet, if not removed timely by the immune surveillance system it will present a detrimental side. Though the latter is attributed to the so called senescence-associated-secretory-phenotype (SASP), recent reports demonstrate that “escape” from senescence may represent another unfavourable outcome.

Wellcome 4-Year PhD Programme in Integrated Molecular, Cellular and Translational Biology

The Wellcome Trust Integrated molecular, cellular and translational biology programme combines scientific excellence with a commitment to improving the working environment and transition support for trainees. This PhD programme, provided by world-renowned scientists from the School of Life Sciences at the University of Dundee, will train the next generation of scientists at the forefront of international science. Students will join our supportive and positive research culture with the opportunity to select research projects centred around four themes:

Sugar-coating proteins can help understand brain disease

A University of Dundee discovery has the potential to help scientists better understand neurological diseases such as Alzheimer’s and Parkinson’s. Researchers, led by Professor Daan van Aalten in the School, have developed a new way to tag proteins in human cells with a small sugar molecule called O-GlcNAc. There are over 20,000 proteins in every human cell and approximately 20% of these contain O-GlcNAc. The exact role played by O-GlcNAc remains a mystery but the molecule is found on proteins related to Alzheimer’s, Parkinson’s, motor neurone disease and intellectual disability.

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