University of Dundee

College of Life Sciences

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SLS Sustainability Team visit UoD waste contractor

The School of Life Sciences Sustainability Action Team recognises that SLS produces quite a large amount of polymer waste, some of which is not biologically contaminated and therefore fit for recycling. In early Autumn, the team visited the sorting facility of NWH, our waste contractor in order to discuss first hand what best practice should be.

The team were met by a number of members of NWH who explained how the facility operates. They were Willie Sinclair, the account manager; Ronnie, the waste specialist and Kevin, the depot manager.

‘Biophysical basis of cellular multi-specificity encoded in a model molecular switch - How does a small GTPase Ran/Gsp1 regulate multiple cellular processes’

Tina graduated from University of Zagreb with a degree in Molecular Biology during which she worked in Ivan Dikic's lab as an undergraduate. Tina did her PhD at MRC-LMB with Sarah Teichmann, working together with Cyrus Chothia and Jane Clarke on the evolution of protein complexes.

Welcome to new group leaders

The School has welcomed three new group leaders in recent months. They are currently establishing their laboratories across three of our divisions. Leeanne McGurk has joined the Division of Cell and Developmental Biology, Megan Bergkessel has joined the Division of Molecular Microbiology while Gabriel Sollberger has joined the Division of Cell Signalling and Immunology.

Leeanne McGurk

Leeanne joins the School from the University of Pennsylvania, Philadelphia where she was a postdoctoral research associate in the laboratory of Nancy Bonini.  

PROTACs go macrocyclic

Researchers in the Ciulli group report a first study describing the idea of a macrocyclic PROTAC. The research was published in the prestigious chemistry journal Angewandte Chemie.

PROTACs (for proteolysis-targeting chimeras) are double-headed molecules composed of a ligand for a target protein and a ligand for an E3 ubiquitin ligase, chemically joined by a flexible linker. The PROTAC simultaneously recruits the target protein and the E3 ligase into close proximity, and this leads to the target protein being destroyed inside the cell.

"Genomic instability and “escape” from oncogene-induced senescence"

Abstract:             Oncogene-induced senescence is considered an important tumor suppressor mechanism. Yet, if not removed timely by the immune surveillance system it will present a detrimental side. Though the latter is attributed to the so called senescence-associated-secretory-phenotype (SASP), recent reports demonstrate that “escape” from senescence may represent another unfavourable outcome.