University of Dundee

Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

Short Code: 
MRCPPU

Marie-Curie ITN PhD Studentship: Discovery and characterization of substrate recognition motifs of Deubiquitinases.

PhD position in the Innovative Training Network UBIMOTIF (ESR8):

Discovery and characterization of substrate recognition motifs of Deubiquitinases

Within the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 860517, the Kulathu lab at the MRC Protein Phosphorylation & Ubiquitylation Unit, University of Dundee is offering a 4 year PhD position for an Early Stage Researcher (ESR).

CSC - Phosphorylation of Rab GTPases in Health & Disease

Phosphorylation is a major posttranslational modification whose disruption is linked to multiple human diseases. Our lab has recently found a link between the Parkinson’s associated protein kinase PINK1 and a subset of Rab GTPases. This project will employ state-of-the-art methods to uncover the regulation of Rabs by PINK1 in cells .

The project will lead to training in a wide array of technologies including mass spectrometry and biochemistry. The lab is also linked to the EMBO network and the student will also benefit from training opportunities in Europe during their studies.

CSC - How does the HOIL-1 component of LUBAC regulate innate immunity?

The Linear Ubiquitin Assembly Complex (LUBAC) contains two E3 ubiquitin ligases, called HOIP and HOIL-1. HOIP catalyses the formation of Met1-linked ubiquitin (also called linear ubiquitin) chains, which are required to activate the IkB kinase (IKK) complex that switches on the master transcription factors of the innate immune system, NF-kB and IRF5 (interferon regulatory factor 5). In contrast, we have recently discovered that HOIL-1 is a remarkable and most unusual E3 ligase that links ubiquitin to serine and threonine residues in proteins by forming ester bonds [1].

CSC- Non-lysine ubiquitination in health and disease

Ubiquitination is a posttranslational modification that regulates all aspects of physiology and aberrant ubiquitination has been implicated with numerous diseases. Ubiquitination is typically considered a posttranslational modification of lysine residues but it is emerging that non-lysine ubiquitination is intrinsic to mammalian biology. This project will use a multidisciplinary approach to understand the cellular function of non-lysine ubiquitination.

Sustainability is the aim of the game for Biotechnology YES 2019 entrepreneurs

An interdisciplinary team from across the Schools of Life Sciences and Medicine will take part in the Biotechnology YES 2019 entrepreneurial competition next month. Anna Segarra Fas (Findlay lab, MRC-PPU), Margarida Trigo (Lambert, Martin and Langston labs, Neuroscience), Saria Mansoor (Dorfmueller lab, MMB) and Tom Snelling (Cohen lab, MRC-PPU) have joined together to form the team Recycle Enterprises (RE).

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