Chemical Biology Probe development for the measurement of Parkinson’s disease risk
Applications are invited for a Postdoctoral Research Assistant to work on a collaborative project between the labs of Satpal Virdee and Miratul Muqit. This interdisciplinary project will develop a high throughput biomarker platform based on chemical probe technology that agnostically measures Parkin E3 ligase activity (Pao et al. Nat Chem Biol 2016). This technology will have great potential for addressing unmet clinical needs relating to the assessment of Parkinson’s disease risk and patient stratification. The scope of the platform will be assessed using a clinical samples from patients and healthy controls, including skin fibroblasts and blood-derived cells. These studies will also provide crucial information on the poorly understood aetiology of Parkinson’s disease in the common sporadic form (90-95%). This exciting Michael J. Fox Foundation funded project has tangible potential for improving patient care. Applicants with experience in biochemistry, chemical biology, ELISA, and cell culture are encouraged to apply. The successful applicant will benefit from working in a multidisciplinary lab with excellent career development opportunity. The MRC-PPU is equipped to the highest international standards. For further details, please consult http://www.ppu.mrc.ac.uk
- PhD, with outstanding academic track record and at least one first authored publication (or on track to publish) in an internationally recognized journal.
- Enthusiasm for multidisciplinary science
- Capable of working in a team, but able to plan and work independently.
- Excellent communication skills and knowledge of the English language.
MRC Protein Phosphorylation and Ubiquitylation Unit (PPU):
This project will be performed in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), based within the School of Life Sciences at the University of Dundee. The MRC-PPU is in a beautiful location overlooking the estuary of the River Tay and embedded within the School of Life Sciences at the University of Dundee which is one of the premier Life Sciences research centres in the world.
The position is available immediately. The appointment will be made on the University of Dundee postdoctoral salary Grade 7 scale plus superannuation with initial placement depending on achievements and experience, but will be up to £35,211, (Spinal Point 32).
This contract is for a fixed term period of 2 years with the possibility of extension.
Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. The initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £31,302).
We are one of the UK’s leading universities – internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee - an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology. Just a short walk from the V&A Museum of Design Dundee, we’re close to both the train and bus stations. We also have campuses at Ninewells Hospital and in Kirkcaldy which are easily accessible via local transport links.
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