A PhD position is available in the laboratory of Ron Hay FRS (www.lifesci.dundee.ac.uk/group s/ron_hay) in the School of Life Sciences University of Dundee, Dundee, UK to study “The role of Arsenic in modulating PML/TRIM19 activity”. The successful applicant would be part of TRIM-NET, a Marie Skłodowska-Curie Action - Innovative Training Networks (GA 813599 – H2020-MSCA-ITN-2018) training network in drug discovery targeting TRIM ubiquitin ligases.
Summary of the project:
ESR9. Arsenic is used therapeutically to treat Acute Promyelocytic Leukaemia by inducing SUMO-dependent, ubiquitin-mediated degradation of the PML-RAR oncoprotein. The objective of the work will be to define the mechanism by which arsenic induces SUMO modification of PML (TRIM19) and will involve a combination of biochemical, proteomic and structural biology approaches.
General description of the network:
The Tripartite motif (TRIM) family of Ubiquitin E3 ligases plays an important role in many physiological processes and in many diseases including cancer, neurodegenerative and neuro-muscular disorders and rare genetic diseases. As such, they are excellent targets for therapeutic manipulation. TRIM-NET is a training programme for Early-Stage Researchers to identify novel therapeutic targets and to develop the strategies to validate them in preclinical studies. The TRIM-NET network will integrate complementary expertise and multidisciplinary approaches to exploit common targeting strategies for translational applications. The consortium will train a cohort of young researchers in skills and expertise essential for biomedical research focusing on: i) determining how TRIM proteins contribute to disease; ii) developing strategies to modulate TRIM protein activity; iii) designing high throughput screening assays for drug discovery. The project consists of 12 individual research projects. As the scientific work packages are highly integrated, recruited students will avail of techniques and training opportunities, including secondments, across the work packages. Through a unique international partnership between academic and non-academic partners the TRIM-NET training programme will provide young researchers with skills required for biomedical research in industry and academia.
Eligibility and requirements:
- Not having a doctoral degree yet
- Less than 4 years full-time research experience
- A degree which entitles to embark on a doctorate in the host countries
- Less than 12 months spent in the host country in the 3 years prior to the recruitment
- A strong background in Biology, Biochemistry, Chemistry, Medicine or related fields according to the individual research projects
Job offer and benefits:
- Attractive salary
- 3-year full-time employment contract in accordance with the Marie Skłodowska-Curie Action regulations for Early Stage Researchers
- Enrollment in a PhD programme at the local partner’s institution. In case the student is enrolled in a doctoral programme in a country where the duration of the PhD study is beyond the 3-year-MSCA contract, additional funding for the additional year(s) will be provided by the host group
- Access to state-of-the-art research and supervision by recognized experts
- Participation in network-wide training activities, schools and conferences
- Secondments periods at other network partners’ labs
Living Allowance – EUR 54,858 per annum
Mobility Allowance – EUR 7,200 per annum
Family Allowance – EUR 6,000 per annum (if eligible)
The exact salary will be calculated in GBPs and will contemplate living, mobility and family (if eligible) allowances.
The project will last 36 months. Students are expected to initiate their contracts before 31 December 2019.
Applications in English should include:
- A cover letter indicating their motivation for the selection of this project and the indication of the countries of residence during the last 3 years
- CV (contact details, education, work experience, list of publications, prizes/awards, language skills,etc...)
- A motivation letter
- A digital copy of the degree certificate and official academic transcripts of Bsc and Msc studies (Master diploma/certificate or equivalent qualification giving access to the Doctoral Programme + Transcript of Records including examinations and scores obtained. If the documents are issued in a language other than English, a translation must be included, along with the original document)
- A documentation of English language qualifications
- Two recommendation letters sent directly by the referees to HR-Life-Sci@dundee.ac.uk with the subject: “TRIM-NET” and full contact details of the reference persons
Please attach this information as a single pdf file to your online application. Equal consideration will be given to female and male applicants.
Deadlines of application, evaluation process and starting date:
- Deadline for Application: 27 September 2019
- The merit-based recruitment process will be on a competitive basis across all applicants for each project
- Students are expected to initiate their contracts before 31 December 2019
We are one of the UK’s leading universities – internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee - an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology. Just a short walk from the V&A Museum of Design Dundee, we’re close to both the train and bus stations. We also have campuses at Ninewells Hospital and in Kirkcaldy which are easily accessible via local transport links.
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