University of Dundee

Senior Biologist

Biological Chemistry and Drug Discovery
Job Reference: 
Closing Date: 
Saturday, June 15, 2019
Grade 8 (£40,792 - £48,677)

We are looking for a highly motivated and experienced malaria or cryptosporidiosis biologist to join our drug discovery group. The appointee will be involved in leading the biology aspects of a portfolio of drug discovery projects for malaria and cryptosporidiosis and integrating them with the chemistry, computational chemistry and pharmacokinetic aspects of the projects. The appointee will gain valuable experience in working with Cryptosporidium through training and collaboration with the Pawlowic lab, based in the Division of Biological Chemistry and Drug Discovery.

The Drug Discovery Unit (DDU) is a fully integrated drug discovery operation based within a world class Life Sciences research environment. The DDU works on both neglected diseases (malaria, cryptosporidiosis, leishmaniasis, Chagas disease and TB) and validation of novel drug targets across a range of therapeutics areas. The DDU works to Biotech style philosophy and standards, incorporating dynamic, goal driven project management. The project goals are programme dependent but range from quality leads demonstrating proof of concept in a disease model, through to pre-clinical candidates. The DDU has a proven track record of delivery of pre-clinical candidates for neglected diseases.

The successful applicant will also be involved in managing interactions and scientific work with a large variety of external collaborators. There will also be line management responsibility.

She/he will be required to report on progress both internally and to collaborators and funding agencies both in report form and through presentations. Where applicable, the post holder will co-ordinate the writing of scientific publications and make presentations at external scientific conferences.

This post is an excellent opportunity for a biologist with a translational mind-set to become an integral member of a team that has already developed one clinical candidate for malaria and aims to develop additional much needed new treatments for malaria and cryptosporidiosis. In addition to a leading role in the apicomplexan drug discovery project the successful candidate will have opportunities to help the drive for innovation within the drug discovery process and best practice within the DDU.

This open-ended position is available immediately. Salary will depend on experience, but will be between £40,792 and £48,677.

Required attributes:

• Candidates must have a PhD in a biological science related discipline or alternatively a BSc in a biological science with subsequent substantial experience.

• Candidate should have a significant track record of working in malaria, cryptosporidiosis or toxoplasma biology with evidence of influencing the strategy or tactics applied to advance a project.

• Candidates should have a track record of answering research questions by applying multiple complementary techniques and approaches by engaging with external experts

• Candidates should have a broad understanding of cellular biology and enzymology sufficient to propose approaches in either discipline to advance projects

• Strong interpersonal, communication and presentation skills

• Good time management, organizational and communication skills.

• Interest in drug discovery and in particular in multidisciplinary interactions between biology, pharmacology, computational and structural biology and medicinal chemistry

• A willingness to work flexibly to meet project milestones

• Ability to take the initiative.

Preferred attributes:

• General mammalian cell culture and microbiology skills

• Experience in setting up, optimising, and running a variety of biochemical and cellular assays, as evidenced through publications and/ or preclinical candidates.

• Experience in line management

A few facts about The School of Life Sciences at Dundee:

• The School of Life Sciences has over 1000 research and support staff from around 60 countries and external funding in excess of £100 million in 2013

• Dundee has twice been named ‘the best place to work in Europe’ in a poll of scientists conducted by The Scientist magazine

• Life Sciences at the University of Dundee is the highest-rated for Biological Sciences in the UK by the main standard of University research performance REF2014.

We are one of the UK’s leading universities – internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee - an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology.

The diversity of our staff and students helps to make the University of Dundee one of the top universities in the UK. Family friendly policies, staff support networks for BME and LGBT staff, membership of Athena SWAN and Stonewall, as well a full range of disability services, create an enjoyable and inclusive place to work.

Dundee, set on the east coast of Scotland, lies in an area of outstanding natural beauty, including large sandy beaches and challenging hills. Dundee is also a vibrant cultural centre. Home to the new V&A Dundee, opened in September 2018 and already hosting its 500,000 visitor; the Dundee Rep and Scottish Dance Theatre; Dundee Contemporary Arts; MacManus Gallery and many individual artists.

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