A two-year MRC-funded Research Fellow position is available with Dr Henry McSorley within the Division of Cell Signalling and Immunology at the University of Dundee.
Parasitic worms secrete a range of immunomodulatory products with potential for use as treatments for allergic and inflammatory diseases. We recently identified the Heligmosomoides polygyrus Alarmin Release Inhibitor (HpARI) which suppresses IL-33 responses (Osbourn, 2017, Immunity). Since then we have developed a range of products capable of suppressing or amplifying the IL-33 pathway, with potential for use in allergic asthma, acute lung injury and pneumonia. In this project we will investigate the use of these parasite products in models of these diseases, and investigate their structure and molecular mechanism of action.
The post-holder will use a broad range of immunological, in vivo and molecular techniques. Parasite-derived immunomodulatory proteins which modulate the IL-33 pathway will be expressed in mammalian expression systems. The activity of these proteins, and the activity of mutants and derivatives of these proteins, will be chacterised in in vitro and in vivo immunological assays (multicolour flow cytometry, multiplex cytokine assays, fluorescent imaging techniques, tissue culture) and in murine models of asthma, acute lung injury and Streptococcus pneumoniae infection. Immunomodulatory proteins will be further assessed in human in vitro and ex vivo immunological assays to ensure translation of results.
The post requires a highly motivated candidate with (or soon to obtain) a PhD in Immunology or a related subject, and expertise in in vitro and in vivo models of inflammation, parasite immunomodulation and protein engineering.
Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. The initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £31,866).
Informal enquiries: HMcsorley001@dundee.ac.uk
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