Summary of Job Purpose and Principal Duties
The Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC PPU, http://www.ppu.mrc.ac.uk/) is a major research facility embedded within the School of Life Sciences at the University of Dundee. Our research is aimed at understanding how protein phosphorylation and ubiquitylation regulates biological processes and how disruptions of pathways controlled by phosphorylation and/or ubiquitylation cause major human diseases such as cancer neurodegeneration and immunity disorders. One of the core technologies used by all of our researchers is mass spectrometry and the MRC-PPU possess a state of the art facility equipped with an Orbitrap Fusion, two Orbitrap VelosPro, a QTrap 5500 and two MALDI-ToF-ToF systems (RapiFlex and UltrafleXtreme).
We are seeking to appoint a highly motivated and experienced scientist with considerable expertise in mass spectrometry to lead major research collaborative projects with our group leaders. The successful applicant will independently work together with our group leaders and staff within their laboratory to design and undertake collaborative mass spectrometry studies. The successful applicant will analyse and interpret proteomics data for publication and grant applications. The post holder will also be involved in the long term development of mass spectrometry systems in the MRC PPU and liaising effectively with the other research staff who work within the MRC PPU mass spectrometry facility. This position provides an exciting opportunity to be involved in world-class research projects and for the successful applicant to carve themselves a major international reputation.
Summary of Skills, Experience and Qualifications
Applicants should have significant experience of proteomics in an academic or industry environment. They should have a significant publication track record and knowledge of the operation mass spectrometers, particularly instruments available within the MRC PPU including Orbitrap Lumos, Exploris, Exactive HF-X or Bruker timsTOF. An excellent knowledge of quantitative proteomics workflows, sample preparation and data analysis of global proteomics and good understanding of statistical knowledge is essential. Previous work with phosphorylation or ubiquitylation post-translational modifications would be advantageous. A good knowledge in Python, R and/or MATLab and ability to write and develop scripts as well as modify and implement open source or published code is also desirable. The ability to work independently and communicate effectively with staff at all levels is also essential.
- Strong expertise in mass spectrometry and quantitative proteomics.
- Knowledge in operation mass spectrometers, particularly Orbitrap Lumos, Exploris, Exactive HF-X or Bruker timsTOF
- Strong expertise in proteomics data analysis.
- Expertise in phosphorylation and/or ubiquitylation biology is desirable.
- PhD with very good academic track record.
- Experience of managing collaborations.
- Interest in signal transduction research and how disruptions of these pathways are linked to human disease.
- Capable of working as part of a team and able to provide leadership to the rest of the team of scientists and technicians.
- Excellent communication skills and knowledge of the English language are essential.
- A good knowledge in Python, R and/or MATLab and ability to write and develop scripts as well as modify and implement open source or published code is desirable.
For further information about this position please contact Paul Davies at email@example.com
MRC Protein Phosphorylation and Ubiquitylation Unit (PPU):
The MRC PPU is one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation (http://www.ppu.mrc.ac.uk/). Many world leading researchers in the field of signal transduction have trained within the MRC PPU. The major aims of the MRC PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease, to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation, to generate reagents and improve technologies. A key remit of the MRC-PPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research.
School of Life Sciences:
The MRC PPU is based within the School of Life Sciences at the University of Dundee is the highest-rated for Biological Sciences in the UK by the main standard of University research performance REF2014 (http://www.lifesci.dundee.ac.uk/). Comprising about 100 research groups, the highest number of citations-per-paper for biological sciences in Europe (2013 and 2014 QS World University Rankings), over £100 million of research income in 2013 and nearly 900 staff from over 60 countries worldwide, the School enjoys a reputation as one of the most dynamic international centres for molecular cell biology, with outstanding laboratory and technology facilities. 'Lateral' and 'vertical' interactions within and between research groups are actively encouraged and 13% of publications in the past 5 years have been collaborations between two or more groups.
'This MRC position is supported by funds which presently run until March 2023. Funding renewal decisions are undertaken by the MRC every 5 years where this post will be reviewed with the possibility of extension for a further 5 years'
The diversity of our staff and students helps to make the University of Dundee one of the top universities in the UK. Family friendly policies, staff support networks for BME and LGBT staff, membership of Athena Swan and Stonewall, as well a full range of disability services, create an enjoyable and inclusive place to work.