The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.
The Drug Discovery Unit (DDU) (see http://www.drugdiscovery.dundee.ac.uk) is a fully integrated drug discovery operation based within a world-class Life Sciences research environment. Our remit is to complement BioPharma activities by tackling both neglected disease drug discovery (leishmaniasis, Chagas disease, TB, Cryptosporidiosis and malaria) and validating novel drug targets across a range of therapeutics areas. The DDU works to Biotech style philosophy and standards incorporating, dynamic, goal driven project management based on Target Product Profiles and Compound Selection Criteria. The project goals are therapeutic area dependent but range from quality leads demonstrating disease model proof of concept, through to pre-clinical development candidates.
We are currently looking for a highly motivated bioanalyst to be part of a BioPharma experienced, multi-disciplinary team in the DDU. The post is available immediately and salary will depend on experience. This is a unique opportunity to gain experience in industry-style drug discovery within an academic setting. The bioanalytical laboratory is well equipped to meet the demands required to support an early drug discovery organisation, with several UHPLC/MS systems including a Waters Xevo TQs and microTQs, a Waters Xevo Qtof, a Thermo Exploris 120 and a Shimadzu Nexera X2 SQ.
- Bioanalytical method development/validation.
- Providing high quality sample analysis in support of all in vivo and in vitro DMPK assays.
- Support and development of established assays to measure physicochemical properties, including assays for lipophilicity, solubility and acid dissociation constants.
- Routine MS and instrument maintenance and the day-to-day running of the laboratory.
- Performing data analysis and relevant quality assurance/quality control of conducted assays.
- Working collaboratively with members of the Drug Discovery Unit and academic and/or industrial collaborators to support drug discovery programmes.
Qualifications and experience needed
- At least a Degree or Masters in chemistry, pharmaceutical sciences or life sciences (or equivalent) and a minimum of 3 years relevant experience in bioanalysis.
- Knowledge of the use of HPLC/UHPLC in the analysis of pharmaceuticals, including chromatographic method development and validation.
- Strong interpersonal, communication and presentation skills.
- An ability to be proactive and to work effectively in teams.
- The capability to work under pressure and multi-task.
- A demonstrated ability to work in an organised manner to standard operating procedures.
- Experience in both in-vitro and in-vivo bioanalysis and bioanalytical method development/validation using UHPLC/MS systems.
- Knowledge of extraction methods (solid- and liquid-phase extraction methods)
- Knowledge and maintenance of high-resolution mass spectrometer systems.
- Knowledge of the use and measurement of common physicochemical properties such as lipophilicity, acid dissociation constants and solubility.
- Knowledge and operation of mass spectrometers with electrospray (ESi) sources connected to liquid chromatography systems.
- Experience of operating WatersTM and Thermo mass spectrometers.
For further information about this position please contact Kevin Read at K.Read@dundee.ac.uk
College / School / Directorate Information
A few facts about The School of Life Sciences at Dundee:
- The School of Life Sciences has over 900 research and support staff from 59 countries and external funding in excess of £40 million per year.
- Dundee has twice been named ‘the best place to work in Europe’ in a poll of scientists conducted by The Scientist magazine.
- The School of Life Sciences has been consistently rated ‘5-star’ (the highest rating) by the UK national Research Assessment Exercise.
Dundee, set on the east coast of Scotland, lies in an area of outstanding natural beauty, including large sandy beaches and challenging hills. Dundee is also a vibrant cultural centre. Home to the new V&A Dundee, opened in September 2018 and already hosting its 500,000th visitor; the Dundee Rep and Scottish Dance Theatre; Dundee Contemporary Arts; MacManus Gallery and many individual artists.
For further information about the local area and the top reasons to live and work in Dundee and Scotland:
Any Additional Information
The Biological Chemistry and Drug Discovery Division and Drug Discovery Unit operate on an external funding basis. The Principal Investigators within these units are highly successful in securing external funding for their multi-disciplinary and highly collaborative research and activities.
The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.