The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching & student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide, the School provides a dynamic, multi-national collegiate & diverse environment with state-of-the-art laboratory, technology & teaching facilities.
We are currently looking for a highly motivated medicinal/organic chemist to join a multi-disciplinary team of drug discovery scientists. This team is engaged in an exciting drug discovery collaboration between Professor Alessio Ciulli (http://www.lifesci.dundee.ac.uk/groups/alessio-ciulli) and Boehringer Ingelheim. Our mission is to discover and develop a class of small-molecule drugs for targeted protein degradation as a novel therapeutic paradigm to treat cancer and other human diseases with serious unmet medical needs. The scientist will be expected to boost the synthetic and structure based PROTAC design approaches the team are taking to accelerate translation of research in this field and to develop degrader drug candidates.
The post is available to start on 1st January 2021. Salary will depend on experience and will be up to £40,322. This is a unique opportunity to gain experience in world-leading industry-style protein degradation drug discovery within an academic setting. The position is available until 31st August 2023.
Your priorities will include:
- Design, synthesize and evaluate compounds across project targets.
- Carrying out data analysis and relevant quality assurance protocols.
- Critically analyse project data and contribute ideas that will drive projects forward.
- Develop team science across the collaboration, working with colleagues across disciplines to enable breakthroughs.
- Report directly to the Team Leader (Will Farnaby) and to the Principal Investigator (Alessio Ciulli).
Who we’re looking for:
- A PhD in organic chemistry, medicinal chemistry or a related discipline is required.
- Outstanding academic or industrial track record.
- Strong interpersonal, communication and presentation skills.
- High level of expertise in synthetic organic chemistry and synthetic route design.
- A demonstrated ability to problem-solve within a team environment.
- A track record of applying sound medicinal chemistry principles to optimize lead compounds.
- Experience applying structure-based drug design approaches.
Appointment on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. In those cases the initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £30,688).
Informal enquiries may be made to Professor Alessio Ciulli, e-mail: firstname.lastname@example.org
We are one of the UK’s leading universities – internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee - an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology. Just a short walk from the V&A Museum of Design Dundee, we’re close to both the train and bus stations. We also have campuses at Ninewells Hospital and in Kirkcaldy which are easily accessible via local transport links.
The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.