University of Dundee

Postdoctoral researcher (functional cell biology and targeting of Cullin RING E3 ubiquitin ligases)

Unit: 
Biological Chemistry and Drug Discovery
Job Reference: 
SLSC0857
Closing Date: 
Saturday, April 24, 2021
Salary: 
Grade 7 (£32,817 - £40,322)

Summary of Job Purpose and Principal Duties

Professor Alessio Ciulli’s laboratory is seeking a postdoctoral researcher to undertake research in collaboration with one of the leading pharmaceutical companies supporting the Division of Signal Transduction Therapy (DSTT). The DSTT facilitates collaborations between some of the world’s major pharmaceutical companies (Boehringer Ingelheim, GlaxoSmithKline, and Merck-Serono) and leading Dundee-based researchers with a proven track record of achievement in understanding and exploiting the fundamental molecular causes of human disease in the fields of cancer, immune-regulation, neurodegeneration and hypertension resulting from disruptions in protein ubiquitylation, phosphorylation and other signalling networks.

The successful applicant will be based within the Ciulli lab in Dundee (http://www.lifesci.dundee.ac.uk/groups/alessio-ciulli), under the auspices of a new Protein Degradation Centre.

We are seeking a highly motivated postdoctoral scientist with research experience in cell signalling and proteomics. They will employ state of the art cell biology, proteomics and biophysical approaches to conduct molecular and functional studies on disease-relevant human Cullin RING E3 ubiquitin ligases. The Ciulli lab has close collaborations and access to facilities available within both the Division of Biological Chemistry and Drug Discovery, the MRC Protein Phosphorylation Unit and more widely within the School of Life Sciences. This set-up will ensure the successful candidate will have access to whatever technologies required to conduct the projects that they are working on, including molecular, biochemical, mass spec proteomics, pharmacological and genetic methodologies including CRISPR/CAS9 knock-out and knock-in technologies. There will be regular opportunity for interaction and to discuss data within the group and with the collaborating pharma company.

Candidate Requirements:

  • PhD in Molecular Biology, Cell Biology, Biochemistry, Proteomics or a related discipline with outstanding academic track record and at least one first authored publication in an internationally recognised peer-reviewed journal.
  • Strong background in Biochemistry, Molecular Cell Biology, or Proteomics is required.
  • Strong interest in signal transduction research and how modulation of these pathways are linked to human disease is expected.
  • Experience with mammalian cells tissue culture and protein-interactions studies inside cells is required.
  • Experience with mass spectrometry-based proteomics (TMT-labeling, SILAC) and proteomics data analysis is required.
  • Experience with gene editing, gene silencing and generation of stable, knock-in or knock-out cell lines would be highly advantageous.
  • Capable of working in a team, but able to plan and work independently.
  • Excellent communication skills and knowledge of the English language are essential.
  • The candidate should have ambitions to become a successful researcher either in academia or the pharmaceutical/biotechnology industry.

Preferred skills:

  • Outstanding academic or industrial track records
  • Experience in cancer research
  • Experience with working with multi-protein complexes
  • Strong data science and computational skills
  • Exceptional time management, organisational and self-motivational skills

Apply Here

Additional Information:

The position is fixed-term.  Funds for this project are available for 2 years in the first instance, with the possibility of an extension thereafter.  The appointment will be made on the University's Grade 7 salary scale.

Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD, in which case the initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale.

The Biological Chemistry and Drug Discovery Division and Drug Discovery Unit operate on an external funding basis. The Principal Investigators within these units are highly successful in securing external funding for their multi-disciplinary and highly collaborative research and activities.

For further information about this position please contact Professor Alessio Ciulli at a.ciulli@dundee.ac.uk

The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high-quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.