University of Dundee

"What can we learn about predatory bacteria using structural biology?"

Event Date: 
Friday, May 14, 2021 - 13:00 to 14:00
Event Location: 
Microsoft Teams
Event Speaker: 
Andrew Lovering
Institution: 
University of Birmingham
Event Type: 
Seminar
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MMB Virtual Seminar

Abstract : Bacterial predators are fascinating organisms that may find general usage as “living antibacterials”. Our lab at the University of Birmingham is chiefly concerned with understanding the tools they use to kill other bacteria and how they regulate the various stages of their unusual lifecycle. Approximately a third of the genome from the model predator Bdellovibrio bacteriovorus encodes for proteins with no discernable homology to those from other (non-predatory) bacteria; this makes structural methods ideal for investigating function. We study these predatory enzymes and protein complexes in-vitro, collaborating with Liz Sockett’s group in Nottingham to tie function in with in-vivo context.