University of Dundee

"The ins and outs of cellular quiescence".

Event Date: 
Monday, May 16, 2022 - 13:00 to 14:00
Event Location: 
MSI Small Lecture Theatre / Zoom
Host: 
Dr Tony Ly
Event Speaker: 
Alexis Barr
Institution: 
MRC London Institute of Medical Sciences
Event Type: 
Seminar
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GRE Hybrid seminar
 

Abstract

It is vital that organisms achieve the correct balance between proliferation and quiescence for normal development and in tissue homeostasis. In cancer, the signalling pathways regulating this balance are perturbed to drive cancer cell proliferation. However, cancer cells also use mechanisms of cellular quiescence as a means to escape the effects of chemotherapy and to remain dormant at metastatic sites. Therefore, to treat cancer and eradicate tumour cells more effectively, it is vital that we understand how cells enter, maintain and exit quiescent states. Our lab combines quantitative, single-cell time-lapse imaging with bioinformatics, proteomics and mathematical modelling to understand the molecular mechanisms that control proliferation-quiescence decisions in human cells.

FFP2 masks must be worn by attendees at all times whilst in SLT (available from DC Reception) 

 

Join Zoom Meeting
https://us02web.zoom.us/j/84331638687?pwd=NmxLUWNycjBjRTBSVFpYaGovMllwUT09 

Meeting ID: 843 3163 8687
Passcode: 721766