University of Dundee

Cell Signalling and Immunology 2014

Auciello, F. R., Ross, F. A., Ikematsu, N. and Hardie, D. G. (2014) Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP. FEBS letters. 588, 3361-3366
doi.   10.1016/j.febslet.2014.07.025
Pubmed.  25084564

Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G. and Alessi, D. R. (2014) Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase. Biochem J. 463, 413-427
doi.   10.1042/BJ20140889
Pubmed.  25177796

Banerjee, S., Buhrlage, S. J., Huang, H. T., Deng, X., Zhou, W., Wang, J., Traynor, R., Prescott, A. R., Alessi, D. R. and Gray, N. S. (2014) Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 457, 215-225
doi.   10.1042/BJ20131152
Pubmed.  24171924

Banerjee, S., Zagorska, A., Deak, M., Campbell, D. G., Prescott, A. R. and Alessi, D. R. (2014) Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1betaMYPT1 phosphatase complex and the SCFbetaTrCP E3 ubiquitin ligase. Biochem J. 461, 233-245
doi.   10.1042/BJ20140408
Pubmed.  24785407

Chang, Y. C., Olson, J., Beasley, F. C., Tung, C., Zhang, J., Crocker, P. R., Varki, A. and Nizet, V. (2014) Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo. PLoS Pathog. 10, e1003846
doi.   10.1371/journal.ppat.1003846
Pubmed.  24391502

Coleman, S. M., Prescott, A. R. and Sleeman, J. E. (2014) Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1. Biochem J. 458, 267-280
doi.   10.1042/BJ20130870
Pubmed.  24354850

Crocker, P. R. and Kannagi, R. (2014) Introduction to special issue: 'emerging roles of siglecs in health and disease'. Glycobiology. 24, 784
doi.   10.1093/glycob/cwu073
Pubmed.  25080408

English, G., Byron, O., Cianfanelli, F. R., Prescott, A. R. and Coulthurst, S. J. (2014) Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK-TssFG subcomplex. Biochem J. 461, 291-304
doi.   10.1042/BJ20131426
Pubmed.  24779861

Gawden-Bone, C., West, M. A., Morrison, V. L., Edgar, A. J., McMillan, S. J., Dill, B. D., Trost, M., Prescott, A., Fagerholm, S. C. and Watts, C. (2014) A crucial role for beta2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells. Journal of cell science. 127, 4213-4224
doi.   10.1242/jcs.151167
Pubmed.  25086067

Gowans, G. J. and Hardie, D. G. (2014) AMPK: a cellular energy sensor primarily regulated by AMP. Biochemical Society transactions. 42, 71-75
doi.   10.1042/BST20130244
Pubmed.  24450630

Guther, M. L., Urbaniak, M. D., Tavendale, A., Prescott, A. and Ferguson, M. A. (2014) High-confidence glycosome proteome for procyclic form trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics. J Proteome Res. 13, 2796-2806
doi.   10.1021/pr401209w
Pubmed.  24792668

Hadad, S. M., Hardie, D. G., Appleyard, V. and Thompson, A. M. (2014) Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 16, 746-752
doi.   10.1007/s12094-013-1144-8
Pubmed.  24338509

Hardie, D. G. (2014) AMPK: positive and negative regulation, and its role in whole-body energy homeostasis. Current opinion in cell biology. 33C, 1-7
doi.   10.1016/
Pubmed.  25259783

Hardie, D. G. (2014) A new protein kinase cascade. Nature reviews. Molecular cell biology. 15, 223
doi.   10.1038/nrm3771
Pubmed.  24622616

Hardie, D. G. (2014) AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels. Annual review of nutrition. 34, 31-55
doi.   10.1146/annurev-nutr-071812-161148
Pubmed.  24850385

Hardie, D. G. and Ashford, M. L. (2014) AMPK: regulating energy balance at the cellular and whole body levels. Physiology. 29, 99-107
doi.   10.1152/physiol.00050.2013
Pubmed.  24583766

Hawley, S. A., Ross, F. A., Gowans, G. J., Tibarewal, P., Leslie, N. R. and Hardie, D. G. (2014) Phosphorylation by Akt within the ST loop of AMPK-alpha1 down-regulates its activation in tumour cells. Biochem J. 459, 275-287
doi.   10.1042/BJ20131344
Pubmed.  24467442

Hunter, R. W., Foretz, M., Bultot, L., Fullerton, M. D., Deak, M., Ross, F. A., Hawley, S. A., Shpiro, N., Viollet, B., Barron, D., Kemp, B. E., Steinberg, G. R., Hardie, D. G. and Sakamoto, K. (2014) Mechanism of action of compound-13: an alpha1-selective small molecule activator of AMPK. Chem Biol. 21, 866-879
doi.   10.1016/j.chembiol.2014.05.014
Pubmed.  25036776

Lipina, C. and Hundal, H. S. (2014) Carnosic acid stimulates glucose uptake in skeletal muscle cells via a PME-1/PP2A/PKB signalling axis. Cellular signalling. 26, 2343-2349
doi.   10.1016/j.cellsig.2014.07.022
Pubmed.  25038454

Lipina, C., Irving, A. J. and Hundal, H. S. (2014) Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system? American journal of physiology. Endocrinology and metabolism. 307, E1-13
doi.   10.1152/ajpendo.00100.2014
Pubmed.  24801388

Liu, R., Iadevaia, V., Averous, J., Taylor, P. M., Zhang, Z. and Proud, C. G. (2014) Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors. Nucleic Acids Res. 42, 5083-5096
doi.   10.1093/nar/gku130
Pubmed.  24526220

Macauley, M. S., Crocker, P. R. and Paulson, J. C. (2014) Siglec-mediated regulation of immune cell function in disease. Nature reviews. Immunology. 14, 653-666
doi.   10.1038/nri3737
Pubmed.  25234143

MacKenzie, K. F., Pattison, M. J. and Arthur, J. S. (2014) Transcriptional regulation of IL-10 and its cell-specific role in vivo. Critical reviews in immunology. 34, 315-345
Pubmed.  24941159

Maher, K., Konjar, S., Watts, C., Turk, B. and Kopitar-Jerala, N. (2014) Cystatin F regulates proteinase activity in IL-2-activated natural killer cells. Protein and peptide letters. 21, 957-965
Pubmed.  24702263

Mahfouz, R., Khoury, R., Blachnio-Zabielska, A., Turban, S., Loiseau, N., Lipina, C., Stretton, C., Bourron, O., Ferre, P., Foufelle, F., Hundal, H. S. and Hajduch, E. (2014) Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight. PLoS One. 9, e101865
doi.   10.1371/journal.pone.0101865
Pubmed.  25058613

McMillan, S. J., Richards, H. E. and Crocker, P. R. (2014) Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model. Immunology letters. 160, 11-16
doi.   10.1016/j.imlet.2014.03.008
Pubmed.  24698729

McMillan, S. J., Sharma, R. S., Richards, H. E., Hegde, V. and Crocker, P. R. (2014) Siglec-E promotes beta2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung. J Biol Chem. 289, 20370-20376
doi.   10.1074/jbc.M114.574624
Pubmed.  24895121

Morrison, V. L., James, M. J., Grzes, K., Cook, P., Glass, D. G., Savinko, T., Lek, H. S., Gawden-Bone, C., Watts, C., Millington, O. R., MacDonald, A. S. and Fagerholm, S. C. (2014) Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype. Nature communications. 5, 5359
doi.   10.1038/ncomms6359
Pubmed.  25348463

Naqvi, S., Martin, K. J. and Arthur, J. S. (2014) CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling. Biochem J. 458, 469-479
doi.   10.1042/BJ20131115
Pubmed.  24438093

Nardi, F., Lipina, C., Magill, D., Hage Hassan, R., Hajduch, E., Gray, A. and Hundal, H. S. (2014) Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A. PLoS One. 9, e92255
doi.   10.1371/journal.pone.0092255
Pubmed.  24632852

Navarro, M. N. and Cantrell, D. A. (2014) Serine-threonine kinases in TCR signaling. Nature immunology. 15, 808-814
doi.   10.1038/ni.2941
Pubmed.  25137455

Navarro, M. N., Feijoo-Carnero, C., Arandilla, A. G., Trost, M. and Cantrell, D. A. (2014) Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naive CD8+ T cells. Science signaling. 7, ra99
doi.   10.1126/scisignal.2005477
Pubmed.  25336615

Navarro, M. N., Goebel, J., Hukelmann, J. L. and Cantrell, D. A. (2014) Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks. Mol Cell Proteomics
doi.   10.1074/mcp.M113.037242
Pubmed.  25266776

Ozanne, J., Prescott, A. R. and Clark, K. (2014) The clinically-approved drugs Dasatinib and Bosutinib induce anti-inflammatory macrophages by inhibiting the Salt-Inducible Kinases. Biochem J
doi.   10.1042/BJ20141165
Pubmed.  25351958

Pirkmajer, S., Kulkarni, S. S., Tom, R. Z., Ross, F. A., Hawley, S. A., Hardie, D. G., Zierath, J. R. and Chibalin, A. V. (2014) Methotrexate Promotes Glucose Uptake and Lipid Oxidation in Skeletal Muscle via AMPK Activation. Diabetes
doi.   10.2337/db14-0508
Pubmed.  25338814

Poncet, N., Mitchell, F. E., Ibrahim, A. F., McGuire, V. A., English, G., Arthur, J. S., Shi, Y. B. and Taylor, P. M. (2014) The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle. PLoS One. 9, e89547
doi.   10.1371/journal.pone.0089547
Pubmed.  24586861

Prescott, A. R., Bales, A., James, J., Trinkle-Mulcahy, L. and Sleeman, J. E. (2014) Time-resolved quantitative proteomics implicates the core snRNP protein SmB together with SMN in neural trafficking. Journal of cell science. 127, 812-827
doi.   10.1242/jcs.137703
Pubmed.  24357717

Rog-Zielinska, E. A., Craig, M. A., Manning, J. R., Richardson, R. V., Gowans, G. J., Dunbar, D. R., Gharbi, K., Kenyon, C. J., Holmes, M. C., Hardie, D. G., Smith, G. L. and Chapman, K. E. (2014) Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1alpha. Cell death and differentiation
doi.   10.1038/cdd.2014.181
Pubmed.  25361084

Sabbattini, P., Sjoberg, M., Nikic, S., Frangini, A., Holmqvist, P. H., Kunowska, N., Carroll, T., Brookes, E., Arthur, S. J., Pombo, A. and Dillon, N. (2014) An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation. Mol Biol Cell. 25, 904-915
doi.   10.1091/mbc.E13-10-0628
Pubmed.  24430871

Stephenson, H. N., Mills, D. C., Jones, H., Milioris, E., Copland, A., Dorrell, N., Wren, B. W., Crocker, P. R., Escors, D. and Bajaj-Elliott, M. (2014) Pseudaminic Acid on Campylobacter jejuni Flagella Modulates Dendritic Cell IL-10 Expression via Siglec-10 Receptor: A Novel Flagellin-Host Interaction. The Journal of infectious diseases. 210, 1487-1498
doi.   10.1093/infdis/jiu287
Pubmed.  24823621

Taylor, P. M. (2014) Role of amino acid transporters in amino acid sensing. The American journal of clinical nutrition. 99, 223S-230S
doi.   10.3945/ajcn.113.070086
Pubmed.  24284439

Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. and Cantrell, D. A. (2014) Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells. PLoS One. 9, e106710
doi.   10.1371/journal.pone.0106710
Pubmed.  25181053

Zaru, R., Edgar, A. J., Hanauer, A. and Watts, C. (2014) Structural and functional basis for p38-MK2 activated Rsk signalling in TLR stimulated dendritic cells. Molecular and cellular biology
doi.   10.1128/MCB.00773-14
Pubmed.  25332232