University of Dundee

2020

Alghamdi AH, Munday JC, Campagnaro GD, Gurvic D, Svensson F, Okpara CE, Kumar A, Quintana JF, Abril MEM, Milić P, Watson L, Paape D, Settimo L, Dimitriou A, Wielinska J, Smart G, Anderson LF, Woodley CM, Kelley SPY, Ibrahim HMS, Hulpia F, Al-Salabi MI, Eze AA, Gudin S, Field M, Dardonville C, Tidwell RR, Carrington M, O'Neill PM, Boykin DW, Zachariae U, de Koning HP. 2020. Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei. eLife. 9:1-33. https://doi.org/10.7554/eLife.56416

Beauchamp E, Yap MC, Iyer A, Perinpanayagam MA, Gamma JM, Vincent KM, Lakshmanan M, Raju A, Tergaonkar V, Tan SY, Lim ST, Dong W-F, Postovit LM, Read KD, Gray DW, Wyatt PG, Mackey JR, Berthiaume LG. 2020. Targeting N-myristoylation for therapy of B-cell lymphomas. Nature Communications. 11:Article 5348. https://doi.org/10.1038/s41467-020-18998-1

Bond A, Testa A, Ciulli A. 2020. Stereoselective synthesis of allele-specific BET inhibitors. Organic and Biomolecular Chemistry. 18(38):7533-7539. https://doi.org/10.1039/D0OB01165G

Butenko A, Hammond M, Field MC, Ginger ML, Yurchenko V, Lukeš J. 2020. Reductionist Pathways for Parasitism in Euglenozoans? Expanded Datasets Provide New Insights. Trends in Parasitology. https://doi.org/10.1016/j.pt.2020.10.001

Cipriano A, Sbardella G, Ciulli A. 2020. Targeting epigenetic reader domains by chemical biology. Current Opinion in Chemical Biology. 57:82-94. https://doi.org/10.1016/j.cbpa.2020.05.006

Davis S, Campello HR, Gallagher T, Hunter WN. 2020. The thermodynamic profile and molecular interactions of a C(9)-cytisine derivative binding acetylcholine binding protein from Aplysia californica. Acta Crystallographica Section F: Structural Biology and Crystallization Communications. F76(Part 2):74-80. https://doi.org/10.1107/S2053230X20001168

De Rycker M, Horn D, Aldridge B, Amewu RK, Barry CE, Buckner FS, Cook S, Ferguson MAJ, Gobeau N, Herrmann J, Herrling P, Hope W, Keiser J, Lafuente-Monasterio MJ, Leeson PD, Leroy D, Manjunatha UH, McCarthy J, Miles TJ, Mizrahi V, Moshynets O, Niles J, Overington JP, Pottage J, Rao SPS, Read KD, Ribeiro I, Silver LL, Southern J, Spangenberg T, Sundar S, Taylor C, Van Voorhis WC, White NJ, Wyllie S, Wyatt PG, Gilbert IH. 2020. Setting our sights on infectious diseases. ACS Infectious Diseases. 6:3-13. https://doi.org/10.1021/acsinfecdis.9b00371

Ermogenous C, Green C, Jackson T, Ferguson M, Lord JM. 2020. Treating age-related multimorbidity: the drug discovery challenge. Drug Discovery Today. https://doi.org/10.1016/j.drudis.2020.06.016

Fersing C, Boudot C, Castera-Ducros C, Pinault E, Hutter S, Paoli-Lombardo R, Primas N, Pedron J, Seguy L, Bourgeade-Delmas S, Sournia-Saquet A, Stigliani JL, Brossas JY, Paris L, Valentin A, Wyllie S, Fairlamb AH, Boutet-Robinet É, Corvaisier S, Since M, Malzert-Fréon A, Destere A, Mazier D, Rathelot P, Courtioux B, Azas N, Verhaeghe P, Vanelle P. 2020. 8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi. European Journal of Medicinal Chemistry. 202:Article 112558. https://doi.org/10.1016/j.ejmech.2020.112558

Fersing C, Boudot C, Paoli-Lombardo R, Primas N, Pinault E, Hutter S, Castera-Ducros C, Kabri Y, Pedron J, Bourgeade-Delmas S, Sournia-Saquet A, Stigliani JL, Valentin A, Azqueta A, Muruzabal D, Destere A, Wyllie S, Fairlamb AH, Corvaisier S, Since M, Malzert-Fréon A, Di Giorgio C, Rathelot P, Azas N, Courtioux B, Vanelle P, Verhaeghe P. 2020. Antikinetoplastid SAR study in 3-nitroimidazopyridine series: identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties. European Journal of Medicinal Chemistry. 206:Article 112668. https://doi.org/10.1016/j.ejmech.2020.112668

Floyd A, Yeoman H, Southern J, Dillon R, Cook S, Fairlamb A, Ferguson M, Horn D, MacLean L, Manthri S, Paterson C, Pearson L, Prescott A, Read K, Shastry L, Svensen N, Thomas J. 2020. Para-site-seeing: Exhibition Catalogue. University of Dundee: University of Dundee. [Exhibition catalogue]. https://doi.org/10.20933/100001171

Ford GA, Lord JM, Ferguson MAJ, Bountra C, Le Couteur DG. 2020. Organizational innovation for developing new medicines that target aging and age-related conditions. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 75(1):87-88. https://doi.org/10.1093/gerona/glz062

Fu DJ, Allen EHA, Hickerson RP, Leslie Pedrioli DM, McLean WHI. 2020. Development of a Corneal Bioluminescence Mouse for Real-Time In Vivo Evaluation of Gene Therapies. Translational Vision Science and Technology. 9(13):Article 44. https://doi.org/10.1167/tvst.9.13.44

Galloway A, Atrih A, Grzela R, Darzynkiewicz E, Ferguson MAJ, Cowling VH. 2020. CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures. Open Biology. 10(2):Article 190306. https://doi.org/10.1098/rsob.190306

Giordani F, Paape D, Vincent IM, Pountain AW, Fernández-Cortés F, Rico E, Zhang N, Morrison LJ, Freund Y, Witty MJ, Peter R, Edwards DY, Wilkes JM, van der Hooft JJJ, Regnault C, Read KD, Horn D, Field MC, Barrett MP. 2020. Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs. PLoS Pathogens. 16(11):Article e1008932. https://doi.org/10.1371/journal.ppat.1008932

Gonzalez-Beltran AN, Masuzzo P, Ampe C, Bakker G-J, Besson S, Eibl RH, Friedl P, Gunzer M, Kittisopikul M, Le Dévédec SE, Leo S, Moore J, Paran Y, Prilusky J, Rocca-Serra P, Roudot P, Schuster M, Sergeant G, Strömblad S, Swedlow JR, van Erp M, Van Troys M, Zaritsky A, Sansone S-A, Martens L. 2020. Community standards for open cell migration data. GigaScience. 9(5):1-11. https://doi.org/10.1093/gigascience/giaa041

Hammond MJ, Nenarokova A, Butenko A, Zoltner M, Lacová Dobáková E, Field M, Lukeš J. 2020. A uniquely complex mitochondrial proteome from Euglena gracilis. Molecular Biology and Evolution. 37(8):2173-2191. https://doi.org/10.1093/molbev/msaa061

Harrison J, Sarkar S, Hampton S, Riley J, Stojanovski L, Sahlberg C, Appelqvist P, Erath J, Mathan V, Rodriguez A, Kaiser M, González-Pacanowska D, Read K, Johansson NG, Gilbert I. 2020. Discovery and Optimisation of a Compound Series active against Trypanosoma cruzi, the causative agent of Chagas’ Disease. Journal of Medicinal Chemistry.

Harrison JR, Sarkar S, Hampton S, Riley J, Stojanovski L, Sahlberg C, Appelqvist P, Erath J, Mathan V, Rodriguez A, Kaiser M, Pacanowska DG, Read KD, Johansson NG, Gilbert IH. 2020. Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease. Journal of Medicinal Chemistry. 63(6):3066-3089. https://doi.org/10.1021/acs.jmedchem.9b01852

Henrici RC, Edwards RL, Zoltner M, van Schalkwyk DA, Hart MN, Mohring F, Moon RW, Nofal SD, Patel A, Flueck C, Baker DA, Odom John AR, Field MC, Sutherland CJ. 2020. The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation. MBio. 11(1):Article e02918-19. https://doi.org/10.1128/mBio.02918-19

Homeyer N, van Deursen R, Ochoa-Montaño B, Heikamp K, Ray P, Zuccotto F, Blundell TL, Gilbert IH. 2020. A platform for target prediction of phenotypic screening hit molecules. Journal of Molecular Graphics & Modelling. 95:1-9. https://doi.org/10.1016/j.jmgm.2019.107485

Innes EA, Chalmers RM, Wells B, Pawlowic MC. 2020. A One Health Approach to Tackle Cryptosporidiosis. Trends in Parasitology. 36(3):290-303. https://doi.org/10.1016/j.pt.2019.12.016

Ishida T, Ciulli A. 2020. E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones . SLAS Discovery. https://doi.org/10.1177/2472555220965528

Izquierdo M, Lin D, O'Neill S, Zoltner M, Webster L, Hope A, Gray DW, Field MC, González-Bacerio J. 2020. Development of a High-Throughput Screening Assay to Identify Inhibitors of the Major M17-Leucyl Aminopeptidase from Trypanosoma cruzi Using RapidFire Mass Spectrometry. SLAS Discovery. https://doi.org/10.1177/2472555220923367

Klein VG, Townsend CE, Testa A, Zengerle M, Maniaci C, Hughes SJ, Chan K-H, Ciulli A, Lokey RS. 2020. Understanding and Improving the Membrane Permeability of VH032-Based PROTACs. ACS Medicinal Chemistry Letters. 11(9):1732-1738. https://doi.org/10.1021/acsmedchemlett.0c00265

Machado FC, Bittencourt-Cunha P, Malvezzi AM, Árico M, Radio S, Smircich P, Zoltner M, Field MC, Schenkman S. 2020. EIF2α phosphorylation is regulated in intracellular amastigotes for the generation of infective Trypanosoma cruzi trypomastigote forms. Cellular Microbiology. 1-19. https://doi.org/10.1111/cmi.13243

Makukhin N, Ciulli A. 2020. Recent advances in synthetic and medicinal chemistry of phosphotyrosine and phosphonate-based phosphotyrosine analogues. RSC Medicinal Chemistry.

Pedron J, Boudot C, Brossas J, Pinault E, Bourgeade-Delmas S, Sournia-Saquet A, Boutet-Robinet E, Destere A, Tronnet A, Bergé J, Bonduelle C, Deraeve C, Pratviel G, Stigliani J-L, Paris L, Mazier D, Corvaisier S, Since M, Malzert-Freon A, Wyllie S, Milne R, Fairlamb AH, Valentin A, Courtioux B, Verhaeghe P. 2020. New 8-nitroquinolinone derivative displaying submicromolar in vitro activities against both Trypanosoma brucei and cruzi. ACS Medicinal Chemistry Letters. 11(4):464-472. https://doi.org/10.1021/acsmedchemlett.9b00566

Quintana JF, Bueren-Calabuig J, Zuccotto F, Zoltner M, Canavate Del Pino R, de Koning HP, Horn D, Field MC. 2020. Instability of aquaglyceroporin (Aqp) 2 contributes to drug resistance in trypanosoma brucei. PLoS Neglected Tropical Diseases. 14(7):Article e0008458. https://doi.org/10.1371/journal.pntd.0008458

Quintana JF, Zoltner M, Field M. 2020. Evolving differentiation in African trypanosomes. Trends in Parasitology.

Raimi O, Hurtado-Guerrero R, Borodkin V, Ferenbach A, Urbaniak M, Ferguson M, van Aalten D. 2020. A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor. RSC Chemical Biology. (1):13-25. https://doi.org/10.1039/c9cb00017h

Ramachandran S, Ciulli A. 2021. Building ubiquitination machineries: E3 ligase multi-subunit assembly and substrate targeting by PROTACs and molecular glues. Current Opinion in Structural Biology. 67:110-119. https://doi.org/10.1016/j.sbi.2020.10.009

Sateriale A, Pawlowic M, Vinayak S, Brooks C, Striepen B. 2020. Genetic Manipulation of Cryptosporidium parvum with CRISPR/Cas9. Mead JR, Arrowood MJ, editors. In Cryptosporidium. New York: Humana Press. pp. 219-228. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-9748-0_13

Simpson LM, Macartney TJ, Nardin A, Fulcher LJ, Röth S, Testa A, Maniaci C, Ciulli A, Ganley IG, Sapkota GP. 2020. Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System. Cell Chemical Biology. 27(9):1164-1180.e5. https://doi.org/10.1016/j.chembiol.2020.06.013

Sparvoli D, Zoltner M, Cheng C-Y, Field MC, Turkewitz A. 2020. Diversification of CORVET tethers facilitates transport complexity in Tetrahymena thermophila. Journal of Cell Science. 133(3):1-18. https://doi.org/10.1242/jcs.238659

Thomas M, De Rycker M, Wall RJ, Spinks D, Epemolu O, Manthri S, Norval S, Osuna-Cabello M, Patterson S, Riley J, Simeons FRC, Stojanovski L, Thomas J, Thompson S, Naylor C, Fiandor JM, Wyatt PG, Marco M, Wyllie S, Read KD, Miles TJ, Gilbert IH. 2020. Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity. Journal of Medicinal Chemistry. 63(17):9523-9539. https://doi.org/10.1021/acs.jmedchem.0c00705

Thomas MG, De Rycker M, Ajakane M, Crouch SD, Campbell L, Daugan A, Fra G, Guerrero C, Mackenzie CJ, MacLean L, Manthri S, Martin F, Norval S, Osuna-Cabello M, Riley J, Shishikura Y, Miguel-Siles J, Simeons FRC, Stojanovski L, Thomas J, Thompson S, Velasco RF, Fiandor JM, Wyatt PG, Read KD, Gilbert IH, Miles TJ. 2020. Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis. RSC Medicinal Chemistry. 11(10):1168-1177. https://doi.org/10.1039/d0md00203h

Thompson AM, O'Connor PD, Marshall AJ, Francisco AF, Kelly JM, Riley J, Read KD, Perez CJ, Cornwall S, Thompson RCA, Keenan M, White KL, Charman SA, Zulfiqar B, Sykes ML, Avery VM, Chatelain E, Denny WA. 2020. Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy. European Journal of Medicinal Chemistry. 207:Article 112849. https://doi.org/10.1016/j.ejmech.2020.112849

Torrie LS, Robinson DA, Thomas MG, Hobrath JV, Shepherd SM, Post JM, Ko EJ, Ferreira RA, Mackenzie CJ, Wrobel K, Edwards DP, Gilbert IH, Gray DW, Fairlamb AH, De Rycker M. 2020. Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase. ACS Infectious Diseases. 6(5):1044-1057. https://doi.org/10.1021/acsinfecdis.9b00453

Wall RJ, Carvalho S, Milne R, Bueren-Calabuig JA, Moniz S, Cantizani-Perez J, MacLean L, Kessler A, Cotillo I, Sastry L, Manthri S, Patterson S, Zuccotto F, Thompson S, Martin J, Marco M, Miles TJ, De Rycker M, Thomas MG, Fairlamb AH, Gilbert IH, Wyllie S. 2020. The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani: ACS Infectious Diseases. ACS Infectious Diseases. 6(3):515-528. https://doi.org/10.1021/acsinfecdis.9b00426

Wang Q, Boshoff HIM, Harrison JR, Ray PC, Green SR, Wyatt PG, Barry CE. 2020. PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis. Science. 367(6482):1147-1151. https://doi.org/10.1126/science.aav5912

Zollman D, Ciulli A. 2020. Structural and Biophysical Principles of Degrader Ternary Complexes. Weinmann H, Crews C, editors. In Protein Degradation with New Chemical Modalities: Successful Strategies in Drug Discovery and Chemical Biology. 74 ed. Royal Society of Chemistry. pp. 14-54. (RSC Drug Discovery Series; 74). https://doi.org/10.1039/9781839160691-00014

Zoltner M, Campagnaro GD, Taleva G, Burrell A, Cerone M, Leung K-F, Achcar F, Horn D, Vaughan S, Gadelha C, Zíková A, Barrett MP, de Koning HP, Field M. 2020. Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes. Journal of Biological Chemistry. 295(24):8331-8347. https://doi.org/10.1074/jbc.RA120.012355

Zoltner M, Del Pino RC, Field MC. 2020. Sorting the Muck from the Brass: Analysis of Protein Complexes and Cell Lysates. Michels PAM, Ginger ML, Zilberstein D, editors. In Trypanosomatids: Methods and Protocols. New York: Humana Press. pp. 645-653. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-0716-0294-2_38