University of Dundee

Cell Signalling and Immunology 2011

Aalto, K., Autio, A., Kiss, E. A., Elima, K., Nymalm, Y., Veres, T. Z., Marttila-Ichihara, F., Elovaara, H., Saanijoki, T., Crocker, P. R., Maksimow, M., Bligt, E., Salminen, T. A., Salmi, M., Roivainen, A. and Jalkanen, S. (2011) Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer. Blood. 118, 3725-3733
doi. 10.1182/blood-2010-09-311076
Pubmed. 21821708

Bax, M., Kuijf, M. L., Heikema, A. P., van Rijs, W., Bruijns, S. C., Garcia-Vallejo, J. J., Crocker, P. R., Jacobs, B. C., van Vliet, S. J. and van Kooyk, Y. (2011) Campylobacter jejuni Lipooligosaccharides Modulate Dendritic Cell-Mediated T Cell Polarization in a Sialic Acid Linkage-Dependent Manner. Infection and immunity. 79, 2681-2689
doi. 10.1128/IAI.00009-11
Pubmed. 21502591

Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G. and Alessi, D. R. (2011) TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. The Biochemical journal. 437, 157-167
doi. 10.1042/BJ20110276
Pubmed. 21548880

Cao, H. and Crocker, P. R. (2011) Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation? Immunology. 132, 18-26
doi. 10.1111/j.1365-2567.2010.03368.x
Pubmed. 21070233

Colbert, J. D., Matthews, S. P., Kos, J. and Watts, C. (2011) Internalisation of exogenous cystatin F suppresses cysteine proteases and induces the accumulation of single-chain cathepsin L by multiple mechanisms. The Journal of biological chemistry
doi. 10.1074/jbc.M111.253914
Pubmed. 21956111

Dahm, R., van Marle, J., Quinlan, R. A., Prescott, A. R. and Vrensen, G. F. (2011) Homeostasis in the vertebrate lens: mechanisms of solute exchange. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 366, 1265-1277

doi. 10.1098/rstb.2010.0299

Pubmed. 21402585


Deng, X., Dzamko, N., Prescott, A., Davies, P., Liu, Q., Yang, Q., Lee, J. D., Patricelli, M. P., Nomanbhoy, T. K., Alessi, D. R. and Gray, N. S. (2011) Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nature chemical biology. 7, 203-205

doi. 10.1038/nchembio.538

Pubmed. 21378983

Dissanayake, K., Toth, R., Blakey, J., Olsson, O., Campbell, D. G., Prescott, A. R. and MacKintosh, C. (2011) ERK/p90(RSK)/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicua. Biochem J. 433, 515-525
doi. BJ20101562 [pii]10.1042/BJ20101562
Pubmed. 21087211

Dixon, M. J., Gray, A., Boisvert, F. M., Agacan, M., Morrice, N. A., Gourlay, R., Leslie, N. R., Downes, C. P. and Batty, I. H. (2011) A screen for novel phosphoinositide 3-kinase effector proteins. Molecular & cellular proteomics : MCP. 10, M110 003178
doi. 10.1074/mcp.M110.003178
Pubmed. 21263009

1Evans, A. M., Hardie, D. G., Peers, C. and Mahmoud, A. (2011) Hypoxic pulmonary vasoconstriction: mechanisms of oxygen-sensing. Current opinion in anaesthesiology. 24, 13-20
doi. 10.1097/ACO.0b013e3283421201
Pubmed. 21157304

Finlay, D. and Cantrell, D. (2011) The coordination of T-cell function by serine/threonine kinases. Cold Spring Harbor perspectives in biology. 3, a002261
doi. 10.1101/cshperspect.a002261
Pubmed. 21421912

Finlay, D. and Cantrell, D. A. (2011) Metabolism, migration and memory in cytotoxic T cells. Nature reviews. Immunology. 11, 109-117
doi. 10.1038/nri2888
Pubmed. 21233853

Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, K. and Hundal, H. S. (2011) Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor kappaB signalling in rat skeletal muscle cells by AMP-activated protein kinase. The Biochemical journal. 435, 463-474
doi. 10.1042/BJ20101517
Pubmed. 21323644

Hadad, S., Iwamoto, T., Jordan, L., Purdie, C., Bray, S., Baker, L., Jellema, G., Deharo, S., Hardie, D. G., Pusztai, L., Moulder-Thompson, S., Dewar, J. A. and Thompson, A. M. (2011) Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast cancer research and treatment. 128, 783-794
doi. 10.1007/s10549-011-1612-1
Pubmed. 21655990

Hardie, D. G. (2011) AMPK and autophagy get connected. The EMBO journal. 30, 2511
doi. 10.1038/emboj.2011.175
Pubmed. 21673730

Hardie, D. G. (2011) Signal transduction: How cells sense energy. Nature. 472, 176-177
doi. 10.1038/472176a
Pubmed. 21490664

Hardie, D. G. (2011) AMPK and autophagy get connected. The EMBO journal. 30, 634-635
doi. 10.1038/emboj.2011.12
Pubmed. 21326174

Hardie, D. G. (2011) Sensing of energy and nutrients by AMP-activated protein kinase. The American journal of clinical nutrition. 93, 891S-896
doi. 10.3945/ajcn.110.001925
Pubmed. 21325438

Hardie, D. G. (2011) Cell biology. Why starving cells eat themselves. Science. 331, 410-411
doi. 10.1126/science.1201691
Pubmed. 21273476

Hardie, D. G. (2011) AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer. Biochemical Society transactions. 39, 1-13
doi. 10.1042/BST0390001
Pubmed. 21265739

Hardie, D. G. (2011) Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism. The Proceedings of the Nutrition Society. 70, 92-99
doi. 10.1017/S0029665110003915
Pubmed. 21067629

Hutten, S., Prescott, A., James, J., Riesenberg, S., Boulon, S., Lam, Y. W. and Lamond, A. I. (2011) An intranucleolar body associated with rDNA. Chromosoma. 120, 481-499
doi. 10.1007/s00412-011-0327-8
Pubmed. 21698343

Jamieson, P. M., Cleasby, M. E., Kuperman, Y., Morton, N. M., Kelly, P. A., Brownstein, D. G., Mustard, K. J., Vaughan, J. M., Carter, R. N., Hahn, C. N., Hardie, D. G., Seckl, J. R., Chen, A. and Vale, W. W. (2011) Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet. Diabetologia. 54, 2392-2403
doi. 10.1007/s00125-011-2205-6
Pubmed. 21667214

Konopatskaya, O., Matthews, S. A., Harper, M. T., Gilio, K., Cosemans, J. M., Williams, C. M., Navarro, M. N., Carter, D. A., Heemskerk, J. W., Leitges, M., Cantrell, D. and Poole, A. W. (2011) Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood. 118, 416-424
doi. 10.1182/blood-2010-10-312199
Pubmed. 21527521

Leslie, N. R., Dixon, M. J., Schenning, M., Gray, A. and Batty, I. H. (2011) Distinct inactivation of PI3K signalling by PTEN and 5-phosphatases. Advances in enzyme regulationdoi. 10.1016/j.advenzreg.2011.09.010
Pubmed. 21930147

Leslie, N. R. and Foti, M. (2011) Non-genomic loss of PTEN function in cancer: not in my genes. Trends in pharmacological sciences. 32, 131-140
doi. 10.1016/
Pubmed. 21236500

Lipina, C. and Hundal, H. S. (2011) Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance. Diabetologia. 54, 1596-1607
doi. 10.1007/s00125-011-2127-3
Pubmed. 21468641

Macintyre, A. N., Finlay, D., Preston, G., Sinclair, L. V., Waugh, C. M., Tamas, P., Feijoo, C., Okkenhaug, K. and Cantrell, D. A. (2011) Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism. Immunity. 34, 224-236
doi. 10.1016/j.immuni.2011.01.012
Pubmed. 21295499

MacPherson, M., Lek, H. S., Prescott, A. and Fagerholm, S. C. (2011) A systemic lupus erythematosus-associated R77H substitution in the CD11b chain of the Mac-1 integrin compromises leukocyte adhesion and phagocytosis. The Journal of biological chemistry. 286, 17303-17310
doi. 10.1074/jbc.M110.182998
Pubmed. 21454473

Miller, G., Matthews, S. P., Reinheckel, T., Fleming, S. and Watts, C. (2011) Asparagine endopeptidase is required for normal kidney physiology and homeostasis. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 25, 1606-1617
doi. 10.1096/fj.10-172312
Pubmed. 21292981

Navarro, M. N., Goebel, J., Feijoo-Carnero, C., Morrice, N. and Cantrell, D. A. (2011) Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes. Nature immunology. 12, 352-361
doi. 10.1038/ni.2008
Pubmed. 21399638

Ostrowski, A., Mehert, A., Prescott, A., Kiley, T. B. and Stanley-Wall, N. R. (2011) YuaB functions synergistically with the exopolysaccharide and TasA amyloid fibers to allow biofilm formation by Bacillus subtilis. Journal of bacteriology. 193, 4821-4831
doi. 10.1128/JB.00223-11
Pubmed. 21742882

Otto, D. M., Campanero-Rhodes, M. A., Karamanska, R., Powell, A. K., Bovin, N., Turnbull, J. E., Field, R. A., Blackburn, J., Feizi, T. and Crocker, P. R. (2011) An expression system for screening of proteins for glycan and protein interactions. Analytical biochemistry. 411, 261-270
doi. 10.1016/j.ab.2010.12.036
Pubmed. 21211507

Pinilla, J., Aledo, J. C., Cwiklinski, E., Hyde, R., Taylor, P. M. and Hundal, H. S. (2011) SNAT2 transceptor signalling via mTOR: A role in cell growth and proliferation? Frontiers in bioscience. 3, 1289-1299
Pubmed. 21622135

Redelinghuys, P., Antonopoulos, A., Liu, Y., Campanero-Rhodes, M. A., McKenzie, E., Haslam, S. M., Dell, A., Feizi, T. and Crocker, P. R. (2011) Early Murine T-lymphocyte Activation Is Accompanied by a Switch from N-Glycolyl- to N-Acetyl-neuraminic Acid and Generation of Ligands for Siglec-E. The Journal of biological chemistry. 286, 34522-34532
doi. 10.1074/jbc.M111.243410
Pubmed. 21835922

Richardson, C., Sakamoto, K., de los Heros, P., Deak, M., Campbell, D. G., Prescott, A. R. and Alessi, D. R. (2011) Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. Journal of cell science. 124, 789-800
doi. 10.1242/jcs.077230
Pubmed. 21321328

Ross, F. A., Rafferty, J. N., Dallas, M. L., Ogunbayo, O., Ikematsu, N., McClafferty, H., Tian, L., Widmer, H., Rowe, I. C., Wyatt, C. N., Shipston, M. J., Peers, C., Hardie, D. G. and Evans, A. M. (2011) Selective expression in carotid body type I cells of a single splice variant of the large conductance calcium- and voltage-activated potassium channel confers regulation by AMP-activated protein kinase. The Journal of biological chemistry. 286, 11929-11936
doi. 10.1074/jbc.M110.189779
Pubmed. 21209098

Sardzik, R., Sharma, R., Kaloo, S., Voglmeir, J., Crocker, P. R. and Flitsch, S. L. (2011) Chemoenzymatic synthesis of sialooligosaccharides on arrays for studies of cell surface adhesion. Chemical communications. 47, 5425-5427
doi. 10.1039/c1cc10745c
Pubmed. 21468399

Van Kasteren, S. I., Berlin, I., Colbert, J. D., Keane, D., Ovaa, H. and Watts, C. (2011) A Multifunctional Protease Inhibitor To Regulate Endolysosomal Function. ACS chemical biologydoi. 10.1021/cb200292c
Pubmed. 21910425

Watson, M. L., Macrae, K., Marley, A. E. and Hundal, H. S. (2011) Chronic Effects of Palmitate Overload on Nutrient-Induced Insulin Secretion and Autocrine Signalling in Pancreatic MIN6 Beta Cells. PloS one. 6, e25975
doi. 10.1371/journal.pone.0025975
Pubmed. 21998735

Watts, C. (2011) The endosome-lysosome pathway and information generation in the immune system. Biochimica et biophysica acta
doi. 10.1016/j.bbapap.2011.07.006
Pubmed. 21782984

Zhou, K., Bellenguez, C., Spencer, C. C., Bennett, A. J., Coleman, R. L., Tavendale, R., Hawley, S. A., Donnelly, L. A., Schofield, C., Groves, C. J., Burch, L., Carr, F., Strange, A., Freeman, C., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Craddock, N., Deloukas, P., Dronov, S., Duncanson, A., Edkins, S., Gray, E., Hunt, S., Jankowski, J., Langford, C., Markus, H. S., Mathew, C. G., Plomin, R., Rautanen, A., Sawcer, S. J., Samani, N. J., Trembath, R., Viswanathan, A. C., Wood, N. W., Harries, L. W., Hattersley, A. T., Doney, A. S., Colhoun, H., Morris, A. D., Sutherland, C., Hardie, D. G., Peltonen, L., McCarthy, M. I., Holman, R. R., Palmer, C. N., Donnelly, P. and Pearson, E. R. (2011) Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nature genetics. 43, 117-120
doi. 10.1038/ng.735
Pubmed. 21186350

Zou, Z., Chastain, A., Moir, S., Ford, J., Trandem, K., Martinelli, E., Cicala, C., Crocker, P., Arthos, J. and Sun, P. D. (2011) Siglecs Facilitate HIV-1 Infection of Macrophages through Adhesion with Viral Sialic Acids. PloS one. 6, e24559
doi. 10.1371/journal.pone.0024559
Pubmed. 21931755

zur Nedden, S., Hawley, S., Pentland, N., Hardie, D. G., Doney, A. S. and Frenguelli, B. G. (2011) Intracellular ATP influences synaptic plasticity in area CA1 of rat hippocampus via metabolism to adenosine and activity-dependent activation of adenosine A1 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31, 6221-6234
doi. 10.1523/JNEUROSCI.4039-10.2011
Pubmed. 21508245