University of Dundee

Cell Signalling and Immunology 2013

Arthur, J. S. and Ley, S. C. (2013) Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol. 13, 679-692
doi. 10.1038/nri3495
Pubmed. 23954936

Berglund, F. M., Weerasinghe, N. R., Davidson, L., Lim, J. C., Eickholt, B. J. and Leslie, N. R. (2013) Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110alpha/PIK3CA but not by HER2 or mutant AKT1. Oncogene. 32, 4417-4426
doi. 10.1038/onc.2012.459
Pubmed. 23085752

Cao, R., Butcher, G. Q., Karelina, K., Arthur, J. S. and Obrietan, K. (2013) Mitogen- and stress-activated protein kinase 1 modulates photic entrainment of the suprachiasmatic circadian clock. Eur J Neurosci. 37, 130-140
doi. 10.1111/ejn.12028
Pubmed. 23127194

Castor, D., Nair, N., Declais, A. C., Lachaud, C., Toth, R., Macartney, T. J., Lilley, D. M., Arthur, J. S. and Rouse, J. (2013) Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases. Mol Cell. 52, 221-233
doi. 10.1016/j.molcel.2013.08.036
Pubmed. 24076219

Cuadrado, E., Jansen, M. H., Anink, J., De Filippis, L., Vescovi, A. L., Watts, C., Aronica, E., Hol, E. M. and Kuijpers, T. W. (2013) Chronic exposure of astrocytes to interferon-alpha reveals molecular changes related to Aicardi-Goutieres syndrome. Brain. 136, 245-258
doi. 10.1093/brain/aws321
Pubmed. 23365100

Dandapani, M. and Hardie, D. G. (2013) AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells? Biochem Soc Trans. 41, 687-693
doi. 10.1042/BST20120351
Pubmed. 23514177

Elcombe, S. E., Naqvi, S., Van Den Bosch, M. W., MacKenzie, K. F., Cianfanelli, F., Brown, G. D. and Arthur, J. S. (2013) Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers. PLoS One. 8, e60086
doi. 10.1371/journal.pone.0060086
Pubmed. 23533666

Elkins, J. M., Wang, J., Deng, X., Pattison, M. J., Arthur, J. S., Erazo, T., Gomez, N., Lizcano, J. M., Gray, N. S. and Knapp, S. (2013) X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor. J Med Chem. 56, 4413-4421
doi. 10.1021/jm4000837
Pubmed. 23656407

Elliott, J. L., Der Perng, M., Prescott, A. R., Jansen, K. A., Koenderink, G. H. and Quinlan, R. A. (2013) The specificity of the interaction between alphaB-crystallin and desmin filaments and its impact on filament aggregation and cell viability. Philos Trans R Soc Lond B Biol Sci. 368, 20120375
doi. 10.1098/rstb.2012.0375
Pubmed. 23530264

Emmerich, C. H., Ordureau, A., Strickson, S., Arthur, J. S., Pedrioli, P. G., Komander, D. and Cohen, P. (2013) Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains. Proc Natl Acad Sci U S A. 110, 15247-15252
doi. 10.1073/pnas.1314715110
Pubmed. 23986494

Fullerton, M. D., Galic, S., Marcinko, K., Sikkema, S., Pulinilkunnil, T., Chen, Z. P., O'Neill, H. M., Ford, R. J., Palanivel, R., O'Brien, M., Hardie, D. G., Macaulay, S. L., Schertzer, J. D., Dyck, J. R., van Denderen, B. J., Kemp, B. E. and Steinberg, G. R. (2013) Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nat Med. 19, 1649-1654
doi. 10.1038/nm.3372
Pubmed. 24185692

Gowans, G. J., Hawley, S. A., Ross, F. A. and Hardie, D. G. (2013) AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation. Cell Metab. 18, 556-566
doi. 10.1016/j.cmet.2013.08.019
Pubmed. 24093679

Groves, M. J., Johnson, C. E., James, J., Prescott, A. R., Cunningham, J., Haydock, S., Pepper, C., Fegan, C., Pirrie, L., Westwood, N. J., Coates, P. J., Ganley, I. G. and Tauro, S. (2013) p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia. Br J Cancer. 109, 2434-2444
doi. 10.1038/bjc.2013.601
Pubmed. 24091621

Hardie, D. G. (2013) AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer. Diabetes. 62, 2164-2172
doi. 10.2337/db13-0368
Pubmed. 23801715

Hardie, D. G. (2013) Metformin-acting through cyclic AMP as well as AMP? Cell Metab. 17, 313-314
doi. 10.1016/j.cmet.2013.02.011
Pubmed. 23473026

Hardie, D. G. (2013) The LKB1-AMPK pathway-friend or foe in cancer? Cancer Cell. 23, 131-132
doi. 10.1016/j.ccr.2013.01.009
Pubmed. 23410967

Hardie, D. G. and Alessi, D. R. (2013) LKB1 and AMPK and the cancer-metabolism link - ten years after. BMC Biol. 11, 36
doi. 10.1186/1741-7007-11-36
Pubmed. 23587167

Hobley, L., Ostrowski, A., Rao, F. V., Bromley, K. M., Porter, M., Prescott, A. R., MacPhee, C. E., van Aalten, D. M. and Stanley-Wall, N. R. (2013) BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm. Proc Natl Acad Sci U S A. 110, 13600-13605
doi. 10.1073/pnas.1306390110
Pubmed. 23904481

Kidder, D., Richards, H. E., Ziltener, H. J., Garden, O. A. and Crocker, P. R. (2013) Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile. J Immunol. 190, 2593-2602
doi. 10.4049/jimmunol.1201172
Pubmed. 23408841

Lek, H. S., Morrison, V. L., Conneely, M., Campbell, P. A., McGloin, D., Kliche, S., Watts, C., Prescott, A. and Fagerholm, S. C. (2013) The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow. J Biol Chem. 288, 14698-14708
doi. 10.1074/jbc.M112.430918
Pubmed. 23585567

Lipina, C., Rastedt, W., Irving, A. J. and Hundal, H. S. (2013) Endocannabinoids in obesity: brewing up the perfect metabolic storm? WIREs Membr Transp Signal. 2, 49-63
doi. 10.1002/wmts.79

Lipina, C., Macrae, K., Suhm, T., Weigert, C., Blachnio-Zabielska, A., Baranowski, M., Gorski, J., Burgess, K. and Hundal, H. S. (2013) Mitochondrial Substrate Availability and its Role in Lipid-Induced Insulin Resistance and Proinflammatory Signalling in Skeletal Muscle. Diabetes
doi. 10.2337/db13-0264
Pubmed. 23733201

MacCallum, S. F., Groves, M. J., James, J., Murray, K., Appleyard, V., Prescott, A. R., Drbal, A. A., Nicolaou, A., Cunningham, J., Haydock, S., Ganley, I. G., Westwood, N. J., Coates, P. J., Lain, S. and Tauro, S. (2013) Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6. Sci Rep. 3, 1275
doi. 10.1038/srep01275
Pubmed. 23429453

MacKenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Noehren, G., Kristariyanto, Y., van den Bosch, M., Mudaliar, M., McCarthy, P. C., Pattison, M. J., Pedrioli, P. G., Barton, G. J., Toth, R., Prescott, A. and Arthur, J. S. (2013) PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway. J Immunol. 190, 565-577
doi. 10.4049/jimmunol.1202462
Pubmed. 23241891

MacKenzie, K. F., Van Den Bosch, M. W., Naqvi, S., Elcombe, S. E., McGuire, V. A., Reith, A. D., Blackshear, P. J., Dean, J. L. and Arthur, J. S. (2013) MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop. Mol Cell Biol. 33, 1456-1467
doi. 10.1128/MCB.01690-12
Pubmed. 23382072

Macrae, K., Stretton, C., Lipina, C., Blachnio-Zabielska, A., Baranowski, M., Gorski, J., Marley, A. and Hundal, H. S. (2013) Defining the role of DAG, mitochondrial function, and lipid deposition in palmitate-induced proinflammatory signaling and its counter-modulation by palmitoleate. J Lipid Res. 54, 2366-2378
doi. 10.1194/jlr.M036996
Pubmed. 23833248

McGuire, V. A., Gray, A., Monk, C. E., Santos, S. G., Lee, K., Aubareda, A., Crowe, J., Ronkina, N., Schwermann, J., Batty, I. H., Leslie, N. R., Dean, J. L., O'Keefe, S. J., Boothby, M., Gaestel, M. and Arthur, J. S. (2013) Cross talk between the Akt and p38alpha pathways in macrophages downstream of Toll-like receptor signaling. Mol Cell Biol. 33, 4152-4165
doi. 10.1128/MCB.01691-12
Pubmed. 23979601

McMillan, S. J., Sharma, R. S., McKenzie, E. J., Richards, H. E., Zhang, J., Prescott, A. and Crocker, P. R. (2013) Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b beta2-integrin-dependent signaling. Blood. 121, 2084-2094
doi. 10.1182/blood-2012-08-449983
Pubmed. 23315163

Morrison, V. L., MacPherson, M., Savinko, T., Lek, H. S., Prescott, A. and Fagerholm, S. C. (2013) The beta2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo. Blood. 122, 1428-1436
doi. 10.1182/blood-2013-02-484998
Pubmed. 23823319

O'Neill, L. A. and Hardie, D. G. (2013) Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature. 493, 346-355
doi. 10.1038/nature11862
Pubmed. 23325217

Ordureau, A., Enesa, K., Nanda, S., Le Francois, B., Peggie, M., Prescott, A., Albert, P. R. and Cohen, P. (2013) DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA. J Biol Chem. 288, 24569-24580
doi. 10.1074/jbc.M113.479550
Pubmed. 23846693

Park, J., Al-Ramahi, I., Tan, Q., Mollema, N., Diaz-Garcia, J. R., Gallego-Flores, T., Lu, H. C., Lagalwar, S., Duvick, L., Kang, H., Lee, Y., Jafar-Nejad, P., Sayegh, L. S., Richman, R., Liu, X., Gao, Y., Shaw, C. A., Arthur, J. S., Orr, H. T., Westbrook, T. F., Botas, J. and Zoghbi, H. Y. (2013) RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Nature. 498, 325-331
doi. 10.1038/nature12204
Pubmed. 23719381

Pattison, M. J., MacKenzie, K. F., Elcombe, S. E. and Arthur, J. S. (2013) IFNbeta autocrine feedback is required to sustain TLR induced production of MCP-1 in macrophages. FEBS Lett. 587, 1496-1503
doi. 10.1016/j.febslet.2013.03.025
Pubmed. 23542035

Pauls, E., Nanda, S. K., Smith, H., Toth, R., Arthur, J. S. and Cohen, P. (2013) Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice. J Immunol. 191, 2717-2730
doi. 10.4049/jimmunol.1203268
Pubmed. 23918981

Philp, A., Mackenzie, M. G., Belew, M. Y., Towler, M. C., Corstorphine, A., Papalamprou, A., Hardie, D. G. and Baar, K. (2013) Glycogen Content Regulates Peroxisome Proliferator Activated Receptor- partial differential (PPAR- partial differential) Activity in Rat Skeletal Muscle. PLoS One. 8, e77200
doi. 10.1371/journal.pone.0077200
Pubmed. 24146969

Poncet, N. and Taylor, P. M. (2013) The role of amino acid transporters in nutrition. Curr Opin Clin Nutr Metab Care. 16, 57-65
doi. 10.1097/MCO.0b013e32835a885c
Pubmed. 23196813

Preston, G. C., Feijoo-Carnero, C., Schurch, N., Cowling, V. H. and Cantrell, D. A. (2013) The Impact of KLF2 Modulation on the Transcriptional Program and Function of CD8 T Cells. PLoS One. 8, e77537
doi. 10.1371/journal.pone.0077537
Pubmed. 24155966

Remenyi, J., van den Bosch, M. W., Palygin, O., Mistry, R. B., McKenzie, C., Macdonald, A., Hutvagner, G., Arthur, J. S., Frenguelli, B. G. and Pankratov, Y. (2013) miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity. PLoS One. 8, e62509
doi. 10.1371/journal.pone.0062509
Pubmed. 23658634

Rolf, J., Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. and Cantrell, D. A. (2013) AMPKalpha1: a glucose sensor that controls CD8 T-cell memory. Eur J Immunol. 43, 889-896
doi. 10.1002/eji.201243008
Pubmed. 23310952

Sargent, F., Davidson, F. A., Kelly, C. L., Binny, R., Christodoulides, N., Gibson, D., Johansson, E., Kozyrska, K., Lado, L. L., Maccallum, J., Montague, R., Ortmann, B., Owen, R., Coulthurst, S. J., Dupuy, L., Prescott, A. R. and Palmer, T. (2013) A synthetic system for expression of components of a bacterial microcompartment. Microbiology. 159, 2427-2436
doi. 10.1099/mic.0.069922-0
Pubmed. 24014666

Saunders, S. P., Goh, C. S., Brown, S. J., Palmer, C. N., Porter, R. M., Cole, C., Campbell, L. E., Gierlinski, M., Barton, G. J., Schneider, G., Balmain, A., Prescott, A. R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y. A., Tavendale, R., Mukhopadhyay, S., Turner, S. W., Madhok, V. B., Sullivan, F. M., Relton, C., Burn, J., Meggitt, S., Smith, C. H., Allen, M. A., Barker, J. N., Reynolds, N. J., Cordell, H. J., Irvine, A. D., McLean, W. H., Sandilands, A. and Fallon, P. G. (2013) Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J Allergy Clin Immunol. 132, 1121-1129
doi. 10.1016/j.jaci.2013.08.046
Pubmed. 24084074

Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y. B., Taylor, P. M. and Cantrell, D. A. (2013) Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol. 14, 500-508
doi. 10.1038/ni.2556
Pubmed. 23525088

Taylor, P. M. (2013) Role of amino acid transporters in amino acid sensing. Am J Clin Nutr
doi. 10.3945/ajcn.113.070086
Pubmed. 24284439

Venigalla, R. K., McGuire, V. A., Clarke, R., Patterson-Kane, J. C., Najafov, A., Toth, R., McCarthy, P. C., Simeons, F., Stojanovski, L. and Arthur, J. S. (2013) PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development. Embo J. 32, 1008-1022
doi. 10.1038/emboj.2013.40
Pubmed. 23463102

Voss, M., Campbell, K., Saranzewa, N., Campbell, D. G., Hastie, C. J., Peggie, M. W., Martin-Granados, C., Prescott, A. R. and Cohen, P. T. (2013) Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with gamma-tubulin. Cell Cycle. 12, 2876-2887
doi. 10.4161/cc.25919
Pubmed. 23966160

Zarrouk, M., Rolf, J. and Cantrell, D. A. (2013) LKB1 mediates the development of conventional and innate T cells via AMP-dependent kinase autonomous pathways. PLoS One. 8, e60217
doi. 10.1371/journal.pone.0060217
Pubmed. 23533675