University of Dundee

Cell Signalling and Immunology 2016

Beatson, R., Tajadura-Ortega, V., Achkova, D., Picco, G., Tsourouktsoglou, T. D., Klausing, S., Hillier, M., Maher, J., Noll, T., Crocker, P. R., Taylor-Papadimitriou, J. and Burchell, J. M. (2016) The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9. Nature immunology. 17, 1273-1281
d.o.i 10.1038/ni.3552
PMC: 27595232

Brown, G. D. and Crocker, P. R. (2016) Lectin Receptors Expressed on Myeloid Cells. Microbiology spectrum. 4d.o.i 10.1128/microbiolspec.MCHD-0036-2016
PMC: 27780012

Choi, J. P., Foley, M., Zhou, Z., Wong, W. Y., Gokoolparsadh, N., Arthur, J. S., Li, D. Y. and Zheng, X. (2016) Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice. PloS one. 11, e0160833
d.o.i 10.1371/journal.pone.0160833
Pubmed: 4981389
PMC: 27513872

Darling, N. J., Toth, R., Arthur, J. S. and Clark, K. (2016) Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages. The Biochemical journald.o.i 10.1042/BCJ20160646
PMC: 27920213

Eftimie, R., Gillard, J. J. and Cantrell, D. A. (2016) Mathematical Models for Immunology: Current State of the Art and Future Research Directions. Bulletin of mathematical biology. 78, 2091-2134
d.o.i 10.1007/s11538-016-0214-9
Pubmed: 5069344
PMC: 27714570

Fogarty, S., Ross, F. A., Vara Ciruelos, D., Gray, A., Gowans, G. J. and Hardie, D. G. (2016) AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2. Molecular cancer research : MCR. 14, 683-695
d.o.i 10.1158/1541-7786.MCR-15-0479
PMC: 27141100

Frost, J., Galdeano, C., Soares, P., Gadd, M. S., Grzes, K. M., Ellis, L., Epemolu, O., Shimamura, S., Bantscheff, M., Grandi, P., Read, K. D., Cantrell, D. A., Rocha, S. and Ciulli, A. (2016) Potent and selective chemical probe of hypoxic signalling downstream of HIF-alpha hydroxylation via VHL inhibition. Nature communications. 7, 13312
d.o.i 10.1038/ncomms13312
Pubmed: 5097156
PMC: 27811928

Grahame Hardie, D. (2016) Regulation of AMP-activated protein kinase by natural and synthetic activators. Acta Pharmaceutica Sinica. B. 6, 1-19
d.o.i 10.1016/j.apsb.2015.06.002
PMC: PMC4724661

Habisov, S., Huber, J., Ichimura, Y., Akutsu, M., Rogova, N., Loehr, F., McEwan, D. G., Johansen, T., Dikic, I., Doetsch, V., Komatsu, M., Rogov, V. V. and Kirkin, V. (2016) Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation. The Journal of biological chemistry. 291, 9025-9041
d.o.i 10.1074/jbc.M116.715474
Pubmed: 4861472
PMC: 26929408

Hansen, K. F., Sakamoto, K., Aten, S., Snider, K. H., Loeser, J., Hesse, A. M., Page, C. E., Pelz, C., Arthur, J. S., Impey, S. and Obrietan, K. (2016) Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome. Learning & memory. 23, 61-71
d.o.i 10.1101/lm.039578.115
Pubmed: 4749831
PMC: 26773099

Hardie, D. G., Schaffer, B. E. and Brunet, A. (2016) AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs. Trends in cell biology. 26, 190-201
d.o.i 10.1016/j.tcb.2015.10.013
PMC: 26616193

Hawley, S. A., Ford, R. J., Smith, B. K., Gowans, G. J., Mancini, S. J., Pitt, R. D., Day, E. A., Salt, I. P., Steinberg, G. R. and Hardie, D. G. (2016) The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels. Diabetes. 65, 2784-2794
d.o.i 10.2337/db16-0058
PMC: 27381369

Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Murillo, A. B., Hawkins, P. T., Stephens, L. R., Lamond, A. I. and Cantrell, D. A. (2016) The cytotoxic T cell proteome and its shaping by the kinase mTOR. Nature immunology. 17, 104-112
d.o.i 10.1038/ni.3314
Pubmed: 4685757
PMC: 26551880

Lipina, C. and Hundal, H. S. (2016) Lipid modulation of skeletal muscle mass and function. Journal of cachexia, sarcopenia and muscled.o.i 10.1002/jcsm.12144
PMC: 27897400

Lipina, C. and Hundal, H. S. (2016) Is REDD1 a Metabolic Eminence Grise? Trends in endocrinology and metabolism: TEM. 27, 868-880
d.o.i 10.1016/j.tem.2016.08.005
Pubmed: 5119498
PMC: 27613400

Lipina, C. and Hundal, H. S. (2016) Modulation of cellular redox homeostasis by the endocannabinoid system. Open biology. 6, 150276
d.o.i 10.1098/rsob.150276
Pubmed: 4852457
PMC: 27248801

Lipina, C., Vaanholt, L. M., Davidova, A., Mitchell, S. E., Storey-Gordon, E., Hambly, C., Irving, A. J., Speakman, J. R. and Hundal, H. S. (2016) CB1 receptor blockade counters age-induced insulin resistance and metabolic dysfunction. Aging cell. 15, 325-335
d.o.i 10.1111/acel.12438
Pubmed: 4783351
PMC: 26757949

Matthews, S. P., McMillan, S. J., Colbert, J. D., Lawrence, R. A. and Watts, C. (2016) Cystatin F Ensures Eosinophil Survival by Regulating Granule Biogenesis. Immunity. 44, 795-806
d.o.i 10.1016/j.immuni.2016.03.003
Pubmed: 4846977
PMC: 27067058

McGuire, V. A. and Arthur, J. S. (2016) Stress-induced haematopoietic stem cell proliferation: new roles for p38alpha and purine metabolism. Stem cell investigation. 3, 64
d.o.i 10.21037/sci.2016.10.07
PMC: 27868046

McGuire, V. A., Rosner, D., Ananieva, O., Ross, E. A., Elcombe, S. E., Naqvi, S., van den Bosch, M. M., Monk, C. E., Ruiz-Zorrilla Diez, T., Clark, A. R. and Arthur, J. S. (2016) IFNbeta production is regulated by p38 MAPK in macrophages via both MSK1/2 and TTP dependent pathways. Molecular and cellular biologyd.o.i 10.1128/MCB.00454-16
PMC: 27795299

McGuire, V. A., Ruiz-Zorrilla Diez, T., Emmerich, C. H., Strickson, S., Ritorto, M. S., Sutavani, R. V., Weibeta, A., Houslay, K. F., Knebel, A., Meakin, P. J., Phair, I. R., Ashford, M. L., Trost, M. and Arthur, J. S. (2016) Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation. Scientific reports. 6, 31159
d.o.i 10.1038/srep31159
Pubmed: 4976367
PMC: 27498693

Meunier, I., Lenaers, G., Bocquet, B., Baudoin, C., Piro-Megy, C., Cubizolle, A., Quiles, M., Jean-Charles, A., Cohen, S. Y., Merle, H., Gaudric, A., Labesse, G., Manes, G., Pequignot, M., Cazevieille, C., Dhaenens, C. M., Fichard, A., Ronkina, N., Arthur, S. J., Gaestel, M. and Hamel, C. P. (2016) A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium. Human molecular genetics. 25, 916-926
d.o.i 10.1093/hmg/ddv624
PMC: 26744326

Moral-Sanz, J., Mahmoud, A. D., Ross, F. A., Eldstrom, J., Fedida, D., Hardie, D. G. and Evans, A. M. (2016) AMP-activated protein kinase inhibits Kv 1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation. The Journal of physiology. 594, 4901-4915
d.o.i 10.1113/JP272032
Pubmed: 5009768
PMC: 27062501

Nanda, S. K., Lopez-Pelaez, M., Arthur, J. S., Marchesi, F. and Cohen, P. (2016) Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1. Journal of immunology. 197, 4266-4273
d.o.i 10.4049/jimmunol.1600788
Pubmed: 5114882
PMC: 27807192

Perdicchio, M., Ilarregui, J. M., Verstege, M. I., Cornelissen, L. A., Schetters, S. T., Engels, S., Ambrosini, M., Kalay, H., Veninga, H., den Haan, J. M., van Berkel, L. A., Samsom, J. N., Crocker, P. R., Sparwasser, T., Berod, L., Garcia-Vallejo, J. J., van Kooyk, Y. and Unger, W. W. (2016) Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells. Proceedings of the National Academy of Sciences of the United States of America. 113, 3329-3334
d.o.i 10.1073/pnas.1507706113
Pubmed: 4812702
PMC: 26941238

Remenyi, J., Bajan, S., Fuller-Pace, F. V., Arthur, J. S. and Hutvagner, G. (2016) The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132. Scientific reports. 6, 22848
d.o.i 10.1038/srep22848
Pubmed: 4780006
PMC: 26947125

Reyskens, K. M. and Arthur, J. S. (2016) Emerging Roles of the Mitogen and Stress Activated Kinases MSK1 and MSK2. Frontiers in cell and developmental biology. 4, 56
d.o.i 10.3389/fcell.2016.00056
Pubmed: 4901046
PMC: 27376065

Ross, F. A., Jensen, T. E. and Hardie, D. G. (2016) Differential regulation by AMP and ADP of AMPK complexes containing different gamma subunit isoforms. The Biochemical journal. 473, 189-199
d.o.i 10.1042/BJ20150910
Pubmed: 4700476
PMC: 26542978

Ross, F. A., MacKintosh, C. and Hardie, D. G. (2016) AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours. The FEBS journal. 283, 2987-3001
d.o.i 10.1111/febs.13698
Pubmed: 4995730
PMC: 26934201

Ross, S. H., Rollings, C., Anderson, K. E., Hawkins, P. T., Stephens, L. R. and Cantrell, D. A. (2016) Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8(+) T Cells. Immunity. 45, 685-700
d.o.i 10.1016/j.immuni.2016.07.022
Pubmed: 5040828
PMC: 27566939

Spoerry, C., Hessle, P., Lewis, M. J., Paton, L., Woof, J. M. and von Pawel-Rammingen, U. (2016) Novel IgG-Degrading Enzymes of the IgdE Protease Family Link Substrate Specificity to Host Tropism of Streptococcus Species. PloS one. 11, e0164809
d.o.i 10.1371/journal.pone.0164809
Pubmed: 5066943
PMC: 27749921

Swamy, M., Pathak, S., Grzes, K. M., Damerow, S., Sinclair, L. V., van Aalten, D. M. and Cantrell, D. A. (2016) Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy. Nature immunology. 17, 712-720
d.o.i 10.1038/ni.3439
Pubmed: 4900450
PMC: 27111141

Tilston-Lunel, A. M., Haley, K. E., Schlecht, N. F., Wang, Y., Chatterton, A. L., Moleirinho, S., Watson, A., Hundal, H. S., Prystowsky, M. B., Gunn-Moore, F. J. and Reynolds, P. A. (2016) Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells. Journal of molecular cell biologyd.o.i 10.1093/jmcb/mjw020
Pubmed: 5055084
PMC: 27190314

Watson, A., Lipina, C., McArdle, H. J., Taylor, P. M. and Hundal, H. S. (2016) Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD1. Cellular signalling. 28, 412-424
d.o.i 10.1016/j.cellsig.2016.01.014
Pubmed: 4804389
PMC: 26827808

Woof, J. M. (2016) Immunoglobulins and their receptors, and subversion of their protective roles by bacterial pathogens. Biochemical Society transactions. 44, 1651-1658
d.o.i 10.1042/BST20160246
PMC: 27913674

Yung, M. M., Ross, F. A., Hardie, D. G., Leung, T. H., Zhan, J., Ngan, H. Y. and Chan, D. W. (2016) Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade. Integrative cancer therapies. 15, 376-389
d.o.i 10.1177/1534735415611747
PMC: 26487740

Zhang, Y., Roth, T. L., Gray, E. E., Chen, H., Rodda, L. B., Liang, Y., Ventura, P., Villeda, S., Crocker, P. R. and Cyster, J. G. (2016) Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node. eLife. 5d.o.i 10.7554/eLife.18156
Pubmed: 5017864
PMC: 27487469

Zhou, Z., Tang, A. T., Wong, W. Y., Bamezai, S., Goddard, L. M., Shenkar, R., Zhou, S., Yang, J., Wright, A. C., Foley, M., Arthur, J. S., Whitehead, K. J., Awad, I. A., Li, D. Y., Zheng, X. and Kahn, M. L. (2016) Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature. 532, 122-126
d.o.i 10.1038/nature17178
Pubmed: 4864035
PMC: 27027284