University of Dundee

Proteomics Specialist

Unit: 
Biological Chemistry and Drug Discovery
Job Reference: 
SLSC0896
Closing Date: 
Wednesday, August 4, 2021
Salary: 
Grade 7 (£32,817 - £40,322)

The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

We are seeking to appoint a highly motivated postdoctoral researcher with appropriate skills in proteomics to join our Mechanism of Action (MoA) group. The MOA group is embedded within the Wellcome Centre for Anti-Infectives Research (WCAIR) (http://www.lifesci.dundee.ac.uk/research/wcair) at the University of Dundee. The vision for the WCAIR is to tackle the urgent unmet medical need and lack of drug discovery research for Neglected Tropical Diseases (NTDs). WCAIR aims to integrate research in fundamental biology and translational research to deliver high-quality pre-clinical drug candidates for the treatment of NTDs.

The MoA group, led by Dr Susan Wyllie (modeofactiondundee.org), determines the mechanism of action and molecular targets of anti-parasitic compounds. Specifically, we contribute to the development of drugs for the treatment of malaria, cryptosporidiosis, schistosomiasis, and kinetoplastid-based diseases. We have developed an integrated drug target deconvolution strategy, employing an array of established and new methodologies encompassing high-throughput genetics, cell biology and chemical proteomics. We work closely with partners in academia and industry, and information emanating from our studies has been vital in guiding numerous drug discovery programmes.  In addition, our recent studies have been published in high-profile journals such as Nature and PNAS.

Your priorities will include:

Main duties/responsibilities

You will be at the forefront of developing chemical proteomic strategies to support drug target deconvolution for parasites. You will receive training in the chemical proteomics approaches that we current employ within the group, including thermal proteome profiling, CETSA and other quantitative proteomics techniques. You will also have the opportunity to contribute to the development of new strategies and technologies in this fast-evolving area of research. Supported by our world-leading proteomics facility (https://proteomics.lifesci.dundee.ac.uk/), you will gain skills in mass spectrometry and use these skills to inform drug discovery. You will engage with project partners and contribute to exciting work to advance the development of therapeutics. As part of WCAIR you will interact with people working in a range of scientific disciplines including: cell and biochemical assay development, high-throughput screening, medicinal chemistry, in vivo models, and drug metabolism and pharmacokinetics.

Who we’re looking for:

Essential skills:

•       A Ph.D. in a relevant subject, such as biochemistry, biotechnology or parasitology.

•       Experience with analysis of “omics” datasets including proteomics, RNASeq, or whole-genome sequencing.

•       Computer and data processing/management skills.

•       Ability to work both independently and/or as part of a team.

•       Good communication skills – written/verbal.

•       Track record of publication in peer-reviewed journals.

Desirable skills:

  •        Experience culturing category 2 pathogens.
  •        Experience of Mass Spectrometry

 

Additional Information:

We are one of the UK’s leading universities – internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee - an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology. Just a short walk from the V&A Museum of Design Dundee, we’re close to both the train and bus stations. We also have campuses at Ninewells Hospital and in Kirkcaldy which are easily accessible via local transport links.

This position will be for 2 years in the first instance. For more information please contact: Susan Wyllie (s.wyllie@dundee.ac.uk) and visit our website (https://modeofactiondundee.org/). Applications should be submitted to the Dundee jobs portal (https://www.dundee.ac.uk/hr/uodrecruitment/jobvacancies/)

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.

The Closing Date is midnight on 4th August 2021.

For further information or to apply for this position please click here