University of Dundee

Postdoctoral Research Assistant

Medical Research Council Protein Phosphorylation and Ubiquitylation Unit
Job Reference: 
Closing Date: 
Monday, July 26, 2021
Grade 7 (£32,817 - £40,322)

Postdoctoral position: Functional characterization and validation of a novel anti-cancer drug target in DNA damage response

MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee

John Rouse’s lab is interested in how cells sense, signal and repair damaged DNA, and how they cope when DNA damage – or other obstacles – block DNA replication. The goal of the lab is to work out the molecular mechanisms underlying DNA damage signalling and repair, and how these processes are controlled by phosphorylation and ubiquitylation. Another major ambition is identifying new anti-cancer drug targets in the DDR arena.

We are looking for a bright enthusiastic individual to join our team to work on an exciting project in collaboration with Pfizer, aimed at investigating a novel anti-cancer drug target in the DDR arena. The 24-month project will involve testing, for example, whether switching off the activity of the target in question is selectively toxic in cells in specific cancer contexts.

The Rouse lab is based in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), based within the School of Life Sciences at the University of Dundee, overlooking the estuary of the River Tay. The MRC-PPU is one of the world’s leading centres for research on role of the protein phosphorylation and ubiquitylation in cell signalling (

The position is fixed-term. Salary will be dependent on experience, but the appointment will be made on the University's Grade 7 salary scale between £32,817 - £36,914.

Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. In this case, the initial appointment would be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £31,866).

Candidate Requirements:

  • PhD with excellent academic track record
  • Ability to work as part of a team, but able to plan and work independently
  • Excellent communication skills 
  • A strong background in mammalian cell work and/or DNA damage signalling/repair

Additional Information:

Informal enquiries should be directed to Prof. John Rouse at

How to Apply:

The University of Dundee is a diverse community and is committed to equality of opportunity for all by providing a supportive, flexible and inclusive working environment. We have family friendly policies (including flexible working and childcare vouchers), staff groups for LGBT and BME; and prayer room facilities.

The University of Dundee is committed to equal opportunities and welcomes applications from all sections of the community.

The University of Dundee is a Scottish Registered Charity, No. SC015096.

The Closing Date is midnight on 26th July 2021.

For further information or to apply for this position please click here