Summary of Job Purpose and Principal Duties
The National Phenotypic Screening Centre (NPSC) is now recruiting a Screening and Assay Technician to support and participate in the development of high content screens as part of its collaboration with the European Lead Factory (ELF). The successful candidate will be motivated, dynamic, scientifically excellent problem solver, reporting to the Academic Lead at the NPSC. They will be highly rigorous with an attention to detail whilst being a capable experimental worker. The successful candidate will be expected to work with NPSC’s assay development cell biologists, the Lead Platform engineer, and partners in the European Lead Factory to deliver 96/384-well cell-based assays to the standard required for high-throughput screening, ensuring that quality assurance tests are executed and evaluated on all of NPSCs systems and that assay development and production assays are properly executed. They will support and participate in the execution screens of compound libraries of up to 50,000 compounds, and then in conjunction with NPSCs assay specialists process, analyse, interpret and report multi-parametric data in conjunction with data/informatics specialists. The position will also require responsibility to assist in compound management/handling and inventory management. The successful candidate will be part of an interdisciplinary team and will have the unique opportunity to work closely with industry scientists and academics/clinicians in a state-of-the-art drug discovery facility.
Summary of Skills, Experience and Qualifications
The ideal candidate will be able to demonstrate or possess the following:
B.Sc. in a relevant biological sciences subject, or equivalent academic or industry experience
Strong background in cell biology with expertise in cell culture and experience with a range of cellular models
Strong background in microscopy and image analysis
Proven experience in assay development and/or quality assurance in an experimental laboratory setting
Ability to work in an interdisciplinary group and manage collaborations
Excellent problem-solving capabilities and a commitment to high levels of quality and scientific rigour
Previous experience with automated liquid handling instruments, QC procedures.
Experience in flow cytometry or immuno-assays (e.g. ELISA)
Ability to perform data and statistical analysis programmatically (e.g. R, Python)
Since its launch in 2015, the National Phenotypic Screening Centre (NPSC) has focused on driving drug discovery efforts for academia and industry using cutting-edge technology to develop complex cell-based assays. The NPSC has significant experience in executing HCS campaigns that utilise a wide variety of image-based technologies including multiplexed fluorescent microscopy assays, live cell time-lapse imaging and high-throughput flow cytometry.
As an internationally diverse institution, we welcome job applicants from all countries and nationalities. The School of Life Sciences is proud to employ staff from over 40 different nations.
The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.